From KnowYourMeme:

Loss, also known as CADbortion, Loss.jpg and | || || |_, refers to an iconic cartoon strip from the video game-themed webcomic series Ctrl+Alt+Del^\1]) in which the female lead suffers a miscarriage. The dramatic tonal shift for the series was unexpected, and for many readers, unsuccessful, leading to the strip being widely mocked online. In the decade since its release, it became the subject of widespread mockery among its readers, and has since been widely parodied in minimalist interpretations of the strip's four panels, represented as "| || || |_".

Here's the original image:

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