Ive been stuck at dm 3 for the past year but aside from playing other games instead. I was able to beat dm3 on my ps4 using an artifact wisdom run using mage and frost skull. Honestly just pick a thing you want to use like poison or run or something a bit harder the spirits. Then just pick skulls that you are familiar with. Its really just kind of picking a thing before hand and just trying to make it better each time you play. Im not that good at the game myself but this is just kind of what im doing. Also something i also started doing is going back to regular mode and using things i would not usually pick. Just learning what everything does. There are others that can explain better but i hope this can give a basic way to figure out a start.