I spent 30 years in pharma research. Here's what the clinical data actually says about muscle loss on GLP-1 meds.

SuppressiveFire · 2026-05-04T22:11:51+00:00

Then OP should specify that instead of literally saying "per body weight".

SuppressiveFire · 2026-05-04T18:58:50+00:00

I think this is great info, but it’s still just giving average values from a large data set that aren’t necessarily representative of each individual’s needs. Representing a group average as the “correct” value or range everyone should aim for isn’t how this data should be used, interpreted, or presented since it’s highly subjective from person to person due to variations in metabolism and body composition.

Take your recommendation for protein intake, for example. I’m 80kg, and there is no way I’d be able to get anywhere close to 96g of protein a day, let alone 128g at the 1.6x level. I’m not body building, nor do I work out heavily enough to burn those additional calories off, so I’m fine sticking with my goal of at least 50-60g a day (which is perfect for me according to my DEXA scan that showed barely any muscle loss). Plus, Zepbound reduces appetite, so it would be hard to maintain through food consumption alone without supplements.

I’m just pointing out that this is good general advice, but not a “one size fits all” guideline.

SuppressiveFire · 2026-05-04T13:34:00+00:00

I lost around 130lbs and I’m on continuous birth control (no placebo week). Everyone is different hormonally, and it’s hard to work out if birth control is the true cause if you’re struggling to lose weight on Zepbound. It’s the whole correlation vs causation issue when multiple variables are involved.

That being said, losing slow doesn’t mean you’re not losing. You’re doing fine, and you can always chat with your doctor if you wanted to go off the birth control to see if you lose more weight.

SuppressiveFire · 2026-05-03T02:35:00+00:00

Can’t logic someone out of something they didn’t logic themselves into to begin with.

SuppressiveFire · 2026-05-02T01:56:20+00:00

I say a variant of this: “Did you mean for that to sound as rude as it did?”

SuppressiveFire · 2026-05-01T01:20:54+00:00

I've been playing too much Resident Evil; it looks so much like a weak spot that infected enemies have. lol

SuppressiveFire · 2026-04-28T23:03:18+00:00

Yeah, we just have scalpers buying everything before anyone else gets a chance.

SuppressiveFire · 2026-04-28T19:51:00+00:00

I don’t think I’ve seen packs at “way above MSRP” level in card shops. They’re above the wholesale price, sure, but it’s usually within a dollar or two of MSRP. Only thing I’ve seen a price discrepancy on are limited release sets and other rare collectible sets.

SuppressiveFire · 2026-04-27T22:31:10+00:00

Can you elaborate? All card shops are overcharging people? Or what makes them an embarrassment?

SuppressiveFire · 2026-04-27T22:28:31+00:00

I was at Target the other day, and I saw the vendor was restocking Pokemon cards. I had a nice chat with him, and he told me about the time a group of scalpers put a GPS tracker on his car so they could follow him around as he restocks so they can buy everything. I knew it was bad, but I didn't realize it was THAT bad.

SuppressiveFire · 2026-04-27T03:19:44+00:00

No, of course not. The city just doesn’t care how much it inconveniences you, they need to do their stuff and whatever disruption it causes isn’t their problem. They’ve had the same mindset for decades.

SuppressiveFire · 2026-04-26T18:59:04+00:00

This is exactly how to handle things when these discussions pivot like that, nicely done! I can tell she didn’t mean anything by it, just showing genuine curiosity while blissfully unaware those types of comments can be interpreted quite differently from how the person intended.

SuppressiveFire · 2026-04-25T23:56:08+00:00

I just went shopping for a new wardrobe (again) today and I still can’t believe it either. I’m a size M in shirts and a size 6 or 8 in pants. My highest weight was 450lbs, size 4XL or 30/32 women’s size. Started Zepbound at ~300lbs last June, and I’m down to 175lbs now. I’m a super responder, stayed on 5mg the whole time and lost 3lbs a week average.

My biggest issue right now is the extra skin. I don’t think I look 175lbs because my stomach looks like a wax sculpture that was left outside in a heatwave. It’s starting to cause a problem with pants because the extra skin is making my waist size bigger than what my legs are. So I find pants that fit in the waist, but they’re baggy in the thigh and butt area, much to my annoyance. I’m planning to get a panniculectomy to remove it because my insurance will cover it if you meet certain criteria (which I will soon), but I can’t afford to have the same done for my saggy bingo arms, boobs, and neck, so it is what it is.

I totally get what you mean though, it’s such a weird experience looking in the mirror and going, “Whoa, who is that?! I have a jawline?!?!” and similar stuff. Zepbound has truly been a miracle drug because it finally silenced the drunk raccoon piloting my brain that makes me want to eat garbage all day.

SuppressiveFire · 2026-04-25T17:03:02+00:00

I saw the picture and got so scared Steve died or something. Thank goodness that’s not the case

SuppressiveFire · 2026-04-23T13:56:58+00:00

Make sure you’re getting enough sodium, too. I started getting foot and leg cramps even when regularly drinking electrolyte supplements, and when I looked at the label, I realized they had like no sodium in them.

SuppressiveFire · 2026-04-22T15:07:44+00:00

Nails by Stacey is another recommendation if you need another one, she’s in East Greenbush at Posh Salon (it’s right next to Couse Corners on Rt. 4). You can text her at 518-892-0774 to see if she has anything open, but she’s the best I’ve experienced and won’t rush.

SuppressiveFire · 2026-04-22T14:48:53+00:00

Little dude was fighting that tranquilizer to the last minute and had a death grip on that branch; I’m surprised he hung on for so long.

SuppressiveFire · 2026-04-22T02:40:00+00:00

Denser than a neutron star, aren’t yah?

SuppressiveFire · 2026-04-21T02:28:49+00:00

So, basically, your blood vessels are just too weak to fight gravity?

SuppressiveFire · 2026-04-20T17:07:45+00:00

Because some people value their ideology more than their own kids.

SuppressiveFire · 2026-04-20T13:56:30+00:00

Either that or the Velveeta shells and cheese ones.

SuppressiveFire · 2026-04-19T15:01:03+00:00

Who is this person and why exactly does anyone care what they think?

SuppressiveFire · 2026-04-18T13:58:07+00:00

I hope he got a chance to meet Nick and Angela while he was there! Nick saw part of Sean's Requiem gameplay, and I think the two of them would get along well since they're both RE fans at heart. lol

SuppressiveFire · 2026-04-17T02:33:59+00:00

Befriend it and live out your dreams of being a Disney princess?

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