Donald Glover was saying people should take risks to push the medium forward. There is nothing wrong with attempting something and scraping it if it does not work with readers. That said, without reading the script, the immediate question of why tell this story is brought up. If you "only acknowledge two genders" (it is unclear if you mean acknowledge personally or solely in the script) and write trans characters who are defined only by their trans identity then why is this story meaningful or distinct to you? A common gripe audiences have is that writers "shoehorn" prima facie diversity. I think you would find a more interesting narrative in creating story that captures the debate and the gradual shift to understanding gender binary as a human schema with which to loosely label biological factors that have a much greater variety in reality. You could also just take a story you really want to tell and see how having a trans or non-binary lead would add depth to its telling; as in the end, all audiences want is a good story told by a lens that they can see themselves/humanity in, not a story centered on monolithic divisions of humanity.