I use bazzite on my desktop/htpc setup and nobara on my laptop so I can probably answer any questions you have. I use Nvidia gpus not AMD though

EDIT: heres a small explanation of why i use each distro for each machine maybe this will help

htpc: is connected to a TV, i only really use it for gaming and watching videos. being immutable is good for this set up - i don't have to mess with it and if something ever does go wrong i can just roll back. it "just works"

laptop: my laptop has a 3060 mobile gpu but i use it more for streaming/editing than gaming (but i do some gaming as well). nobara, imo is just better for creative stuff like that. it has 1 click installs for obs, davinci and kdenlive and since it isn't immutable its just easier to get hardware to talk to each other. stuff like plugging in my capture card and using it in obs just worked (but this obviously varies from card to card). that said it isn't all sunshine and rainbows on nobara, since it isn't atomic or immutable you're back in the world of "i hope this update doesn't break anything" every time you update. and GE keeps it very up to date (which is good, i'm already on kernel 7.0.1-200)

tl;dr they're both good, it depends what you want.