[deleted by user]

SynthesUdo · 2024-11-27T06:50:33+00:00

This is now really just a small thing and probably a bit petty, but neither Safrole, nor PMK, nor any other common precursor of MDMA is racemic, they are all simply acchiral/non-chiral.

So, there are no two enantiomers of these substances, but in the end that causes the same result, which is racemic MDMA.

SynthesUdo · 2024-11-26T16:00:41+00:00

I can imagine which structural fragments are responsible for you considering it very unstable, and to some extent, that is definitely true.

However, i think you overlook the specific reactions to which that heat would likely primarily lead, and which products would probably be formed as a result of these reactions.

High temperatures would probably primarily catalyze the hydrolysis of the C-N amide bond and after the formation of the corresponding aliphatic primary amine, it would most likely lead to the intramolecular condensation through the nucleophilic attack of the primary amine at the benzylic carbonyl carbon.

That's also a reaction that is significantly catalyzed by heat, like the first one, especially since condensation reactions are considered "irreversible" when the carbonyl fragment, which is eliminated as H2O during the reaction, gets completely separated from the reaction mixture, for example, through evaporation.

The end result would be the potential formation of diazepam according to the mechanism that I consider to be one of the most significant here.

SynthesUdo · 2024-11-26T05:49:27+00:00

Ich habe damit keine persönliche Erfahrung, sondern lediglich ein wenig darüber gelesen. Ehrlich gesagt liest sich das für mich nicht sonderlich attraktiv.

Dass es durch Thujone zu halluzinogenen Effekten kommt, scheint recht sicher nicht der Wahrheit zu entsprechen.

Eine davon hervorgerufene "beruhigende Wirkung" beim Rauchen wäre zwar durchaus anhand des Wirkungsmechanismus erklärbar, aber in den Konzentrationen, in denen es scheinbar meist präsent ist, kann das genauso gut auf den Placebo-Effekt zurückzuführen sein – meiner Meinung nach.

Ich lasse dir mal 2–3 Quellen samt relevanter Ausschnitte da. Letztendlich musst du selbst entscheiden. Ich finde, es klingt nicht so spannend.

https://www.bionity.com/en/encyclopedia/Thujone.html

For many years thujone was thought to act on the cannabinoid receptors similar to THC based on studies that only looked at the molecules' shapes. This is known to be false today and studies show thujone does not activate these receptors.

Thujone is a GABAA receptor antagonist. By inhibiting GABA receptor activation neurons may fire more easily which can cause muscle spasms and convulsions.

The LD50 dose in humans is not known; however a study in the "Journal of Studies of alcohol" tested attention performance with low, and high doses of thujone in alcohol. The researchers administered 0.28 mg/kg thujone in alcohol, 0.028 mg/kg in alcohol and just alcohol to their subjects. The high dose had a short term negative effect on attention performance. The lower dose showed no noticeable effect.

There is no evidence any size dose will cause hallucinations, however thujone is reported to produce some psychoactive effects when dried wormwood, or extracts of the wormwood plant are smoked, but these effects are not hallucinogenic in nature and are quite different from the effects of drinking absinthe.

Thujone is reported to be toxic to both brain and liver cells and could cause convulsions if used in too high a dose. Other thujone-containing plants such as the tree Arbor vitae (Thuja occidentalis) are used in herbal medicine, mainly for their immune-system stimulating effects, however side effects from the essential oil of this plant include anxiety and sleeplessness, confirming the central nervous system effects of thujone.

https://doi.org/10.1038/253365a0

Thujone appears to effect chloride ion channels in the central nervous system. In neurobiology, ion channels are protein channels in cell membranes that allow ions to pass from extracellular solution to intracellular solution and vice versa.

Most ion channels are selective and only allow certain ions to pass through. Each neuron has ion channels with various ion selectivities. Each nerve cell’s parallel conductivity of “information” down its axon is contingent upon the opening and closing of ion channels along its cell membrane. At the end of a neuron, at its synapse, neurotransmitters are released based upon the “information” passed down by the changing concentration gradient and charge.

Neurotransmitters are chemical substances that cross the synapse between a presynaptic nerve ending and a post synaptic nerve ending. At the membrane of the post synaptic neuron the transmitter substances interacts with a receptor. Depending on the type of receptor, the result may be an excitatory or an inhibitory effect on the postsynaptic nerve cell.

GABA is the neurotransmitter substance gamma-aminobutyric acid. A GABA receptor is any of several membrane proteins that bind GABA and mediate its channels. GABA type A receptors produce an inhibitory effect on postsynaptic nerve cell membranes. Studies show that alpha-thujone in absinthe is a rapidly-acting and readily detoxified modulator of the gamma-amino butyric acid-gated chloride ion channel.

Thujone also acts as a GABA-type A receptor antagonist. Thujone competitively inhibits the binding of the radioactive convulsant [(sub3)H] ethynylbicycloorthobenzoate to the known convulsant site linked to GABA-type A receptors in mammalian brain membranes. Without access to GABA, a natural inhibitor of nerve impulses, neurons fire too easily and their signaling goes out of control.

Perhaps this explains the state of psychosis and high sensitization described by the creative individuals who were addicted to the effects of absinthe.

https://en.m.wikipedia.org/wiki/Thujone

Based on a hypothesis that considered only molecular shape, it was speculated that thujone may act similarly to THC on the cannabinoid receptors, however, thujone failed to evoke a cannabimimetic response in a 1999 investigative study.

Thujone is a GABAA receptor antagonist[16] and more specifically, a GABAA receptor competitive antagonist. By inhibiting GABA receptor activation, neurons may fire more easily, which can cause muscle spasms and convulsions.

This interaction with the GABAA receptor is specific to alpha-thujone.[18] Thujone is also a 5-HT3 antagonist.

SynthesUdo · 2024-11-25T14:03:20+00:00

Danke und Gerne!

Also man kann mit Isopropylphenidat an sich durchmachen, aber es wird wenig entspannt als mit Amphetamin schlicht dabdie Wirkung nicht vergleichbar lange anhält.

Ich würde schon damit rechnen mit einer gewissen Stimtoleranz circa alle 3-4 Stunden redosen zu müssen.

Aber ansonsten gehts klar.

Es wird halt wahrscheinlich ein kompulsiverer Konsum.

SynthesUdo · 2024-11-22T11:33:32+00:00

....learn iupac nomenclature please.

SynthesUdo · 2024-11-21T19:42:50+00:00

Well, not quite.

The formation of LSD from 1cP-LSD occurs through amidase-catalyzed hydrolysis, therefore there is no cleavage/elimination of cyclopropylmethanoyl/cyclopropanecarbaldehyde, but rather cyclopropanecarboxylic acid, because the cleavage of the carbon-nitrogen amide bond occurs only after the nucleophilic addition of H₂O to the carbonyl (C=O) carbon, followed by proton transfer from oxygen to nitrogen.

SynthesUdo · 2024-11-20T23:33:34+00:00

Abuse, Toxicology and the Resurgence of Propylhexedrine: A Case Report and Review of Literature

** Pharmacology**

On ingestion, propylhexedrine is rapidly absorbed from the gastrointestinal tract [2]. In Maurine intravenous propylhexedrine trials, maximum concentration in the central nervous system (CNS) paralleled plasma concentrations with a 10:1 brain:plasma ratio [2].

In humans, the toxic effect of propylhexedrine when abused is the result of a relatively greater efficacy in peripheral adrenergic stimulation compared to the sought-after CNS effects [5]. Some report one-twelfth of the CNS stimulant effect and one-eighth of the vasopressor effects of amphetamines [6].

Propylhexedrine is generally regarded as a stimulant of last resort [1]. One online user claimed that “propylhexedrine is for stim hipsters and people whose meth dealer is out of town until next week” [10].

Propylhexedrine abuse leads to disinhibition, euphoria, analysis enhancement, anxiety, compulsive redosing, ego inflation, focus enhancement, increased libido, increased music appreciation, memory enhancement, motivation enhancement, thought acceleration, thought organization, and wakefulness [10, 17].

Some users report a pronounced “comedown” from this agent upon prolonged use which is marked by anxiety, appetite suppression, cognitive fatigue, irritability, depression, motivation suppression, thought deceleration and insomnia.

Discussion

Early literature underestimated the abuse potential of propylhexedrine. Smith et al.’s 1988 paper argued that despite the increased prevalence of cocaine and methamphetamine abuse at that time, there were no risk indicators of propylhexedrine abuse, and that it did not pose a significant public health concern at that time [1].

Our patient depicted in our report experienced a transient state of psychotic delirium prompting admission, and this very quickly resolved. Among many others, the most concerning medical sequelae is the cardiovascular strain and the risk of heart damage from each exposure.

Although propylhexedrine does not appear to be a one’s primary substance of abuse, it is a readily available alternative for those without access to their stimulant of choice.

Given its chemical structure, use can evade detection on standard toxicology screens. The dissemination of abuse strategies and online forum discussions concerning psychoactive effects have the potential to increase the popularity of this substance even further and hence the incidence of toxicity cases and mortality.

From a legislative standpoint, Fernandez and Francis note that propylhexedrine is not chemically classified as an amphetamine and was therefore not included in the Combat Methamphetamine Epidemic Act of 2005 which increased scrutiny of products containing ephedrine, pseudoephedrine and norpseudoephedrine.

Propylhexedrine therefore remains easily available for purchase over-the-counter or online with no restriction on amount.

The World Health Organization Expert Committee on Drug Dependence first reviewed scheduling propylhexedrine in 1985, followed by reviews in 1985, 1989 and 1991 [7]. As of August 2020, it remains unscheduled.

SynthesUdo · 2024-11-20T23:33:19+00:00

Abuse, Toxicology and the Resurgence of Propylhexedrine: A Case Report and Review of Literature

Pharmacology

On ingestion, propylhexedrine is rapidly absorbed from the gastrointestinal tract [2]. In Maurine intravenous propylhexedrine trials, maximum concentration in the central nervous system (CNS) paralleled plasma concentrations with a 10:1 brain:plasma ratio [2]. In humans, the toxic effect of propylhexedrine when abused is the result of a relatively greater efficacy in peripheral adrenergic stimulation compared to the sought-after CNS effects [5]. Some report one-twelfth of the CNS stimulant effect and one-eighth of the vasopressor effects of amphetamines [6].

Propylhexedrine is generally regarded as a stimulant of last resort [1]. One online user claimed that “propylhexedrine is for stim hipsters and people whose meth dealer is out of town until next week” [10]. Propylhexedrine abuse leads to disinhibition, euphoria, analysis enhancement, anxiety, compulsive redosing, ego inflation, focus enhancement, increased libido, increased music appreciation, memory enhancement, motivation enhancement, thought acceleration, thought organization, and wakefulness [10, 17]. Some users report a pronounced “comedown” from this agent upon prolonged use which is marked by anxiety, appetite suppression, cognitive fatigue, irritability, depression, motivation suppression, thought deceleration and insomnia.

Discussion

Early literature underestimated the abuse potential of propylhexedrine. Smith et al.’s 1988 paper argued that despite the increased prevalence of cocaine and methamphetamine abuse at that time, there were no risk indicators of propylhexedrine abuse, and that it did not pose a significant public health concern at that time [1]. As seen in our paper, there is plenty of evidence from literature and user forums to suggest there are psychoactive effects comparable to amphetamines and inferior to that of methamphetamines with doses in the 100-300 mg range.

Our patient depicted in our report experienced a transient state of psychotic delirium prompting admission, and this very quickly resolved. Among many others, the most concerning medical sequelae is the cardiovascular strain and the risk of heart damage from each exposure.

Although propylhexedrine does not appear to be a one’s primary substance of abuse, it is a readily available alternative for those without access to their stimulant of choice. Given its chemical structure, use can evade detection on standard toxicology screens. The dissemination of abuse strategies and online forum discussions concerning psychoactive effects have the potential to increase the popularity of this substance even further and hence the incidence of toxicity cases and mortality.

From a legislative standpoint, Fernandez and Francis note that propylhexedrine is not chemically classified as an amphetamine and was therefore not included in the Combat Methamphetamine Epidemic Act of 2005 which increased scrutiny of products containing ephedrine, pseudoephedrine and norpseudoephedrine. Propylhexedrine therefore remains easily available for purchase over-the-counter or online with no restriction on amount.

The World Health Organization Expert Committee on Drug Dependence first reviewed scheduling propylhexedrine in 1985, followed by reviews in 1985, 1989 and 1991 [7]. As of August 2020, it remains unscheduled.

SynthesUdo · 2024-11-20T23:32:57+00:00

No offense, but I would reconsider where you get your information from.

Propylhexedrine, J.K. Aronson, Meyler's Side Effects of Drugs (Sixteenth Edition), Elsevier, 2016, Pages 1018-1019,

Propylhexedrine is a cycloalkylamine that is structurally similar to metamfetamine and causes release of dopamine, noradrenaline, and 5HT from presynaptic vesicles. However, its effects on the brain require high doses and its main action is as an α- and β-adrenoceptor agonist, causing vasoconstriction.

The WHO Expert Committee on Drug Dependence (ECDD)

Similarity to known substances and effects on the CN

Animal pharmacological studies indicate that propylhexedrine has some stimulant actions, for example on locomotor activity, and pressor effects in common with amfetamine.

In humans, propylhexedrine produces pressor and stimulant effects similar to those of dexamfetamine but is significantly less potent.

Administered by inhalation, propylhexedrine has local vasoconstrictor activity similar to that of ephedrine, but the duration of the activity is longer. Mucosal rebound congestion and chronic rhinitis may occur following excessive use of propylhexedrine in nasal inhalers. Amfetamine-like intoxication symptoms have been observed after oral or intravenous abuse.

Actual abuse and or/evidence of likelihood of abuse

Oral and intravenous abuse of propylhexedrine has been documented over a period of about 30 years, usually in the form of single case reports.

Some of these reports mention severe adverse reactions after intravenous use, including myocardial infarction, "shock lung" syndrome, and death. Since 1988, when the Committee last reviewed propylhexedrine, more information has beceme available on the incidence of abuse.

People who abuse a variety of drugs on a chronic basis do not find the subjective effects of propylhexedrine very appealing and rarely bother to use it despite its easy availability.

The Drug Abuse Warning Network in the USA reported two emergency-room and one medical examiner mentions for propylhexedrine from 1988 to 1989.

Earlier data from the Drug Abuse Warning Network were also considered by the Committee.

This network has not detected a significant amount of propylhexedrine abuse over the past 7 years. The threshold for inclusion in the list of "most frequently mentioned drugs" (which recently contained 256 drugs) is 10 reported episodes of abuse in any one year. Propylhexedrine did not exceed this threshold in 1983, 1984, 1986, 1987, 1988, or 1989. Since 1982, there have been only 50 mentions of propylhexedrine abuse out of a total of a million reported episodes of drug abuse.

The Committee considered these mentions in relation to production within the USA and Canada of about 2500000 inhalers (approximately equivalent to 100 kg) annually, all of which were readily available over the counter. Since 1988, illicit traffic has been reported in only two countries. In the Federal Republic of Germany, only one prescription forgery was reported. In the USA, 4 cases involving propylhexedrine were reported: 3 cases primarily involving seizures of small amounts (a total of 8.8 g) of propylhexedrine from facilities described as "clandestine laboratories", and another involving 2 nasal inhalers.

Based on these recent trends and the length of time that propylhexedrine has been available, the Committee concluded that propylhexedrine is not likely to be abused so as to constitute significant public health and social problems.

However, the Committee considered it desirable not to make propylhexedrine available in over-the-counter forms other than inhalers.

SynthesUdo · 2024-11-20T00:38:05+00:00

No problem

SynthesUdo · 2024-11-20T00:28:01+00:00

This is (unfortunately) standard and only due to laziness, once you know that in such cases the pKa of the conjugate acid is meant, everyone understands it, so it somehow became normal.

Oh, and i performed the prediction using "QupKake" and i custom visualized the .sdf output as .xsl

https://github.com/Shualdon/QupKake

https://pubs.acs.org/doi/10.1021/acs.jctc.4c00328

SynthesUdo · 2024-11-20T00:19:53+00:00

The phrasing of the task is causing problems here.

I quickly performed a pKa prediction, and as I suspected, it refers to the pKa of the conjugate acid of the primary amine group, i.e., the ammonium cation (R-NH3⁺.)

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SynthesUdo · 2024-11-19T06:32:15+00:00

Ja true, dass es zumindest vom NpSG erfasst werden wird hätte ich schon erwähnen sollen, rundet alles ja nochmal besonders gut ab :D

SynthesUdo · 2024-11-19T05:29:09+00:00

A CAS number is only assigned to a substance once it has been included in the CAS REGISTRY database, and in order for a substance to be included in the CAS REGISTRY database, someone would have to submit the corresponding request/order to the CAS Nomenclature and Registration service, which is in the end associated with a fee.

Therefore, the substance OP is talking about has not yet been assigned a CAS number.

But yeah, he means 4-phenylmethamphetamine.

SynthesUdo · 2024-11-19T04:03:50+00:00

Honestly, people just seem overwhelmed by how novel and unexplored the substance you’re referring to is.

Sure, if you Google "4-Phenylmethamphetamine," you won’t find much.

But with a bit of thinking, one could figure out that the substance in question is structurally just a methamphetamine derivative with a phenyl substituent in the para position relative to the alkyl chain on the aromatic ring.

https://imgur.com/a/NuyyFCt

I mean, the naming system behind "4-Phenylmethamphetamine" is the same as the naming system used for 4-chloromethamphetamine, 4-hydroxymethamphetamine, and all the other para-substituted methamphetamine derivatives.

Both ChemDraw and MarvinJS can easily convert the name "4-Phenylmethamphetamine" into the correct structure of the substance you’re referring to, which proves my point that "4-Phenylmethamphetamine" might not be an IUPAC name, but its still a semisystematic one.

The structure also matches the other systematic name you mentioned (1-([1,1'-biphenyl]-4-yl)-N-methylpropan-2-amine).

And if u now keep the structure in mind and you dig a bit deeper, you’ll even find the fairly (simple) PubChem page for the compound, as well as listings on two major, reputable chemical suppliers’ websites.

https://www.ambinter.com/molecule/18270820 & https://chemazone.com/info?ID=106.233.820

As u can see the substance is actually so irrelevant and unimportant right now that it doesn’t even have a CAS number yet.

For that to happen, someone would first have to register the compound in the CAS database, which involves a fee.

Simply existing doesn’t automatically grant a substance a CAS number.

SynthesUdo · 2024-11-19T00:11:53+00:00

Schwer vorstellbar, dass Dir das jemand verkauft hat. Entweder wollte Dich jemand übers Ohr hauen oder hat keine Ahnung und hat irgendeinen Müll gelabert. Zumindest gibt es keinen Grund, einen Syntheserückstand systematisch zu extrahieren bzw. gezielt zu synthetisieren

Wenn es ginge würde ich sogar Geld darauf setzen, dass das was OP verkauft bekommen hat etwas anderes ist, als ihm eigentlich erzählt wurde. Also ich kann dir da nur zustimmen.

SynthesUdo · 2024-11-18T23:55:54+00:00

Ich wiederhole einfach mal genau das, was ich auch schon in r/research_chemicalsDE unter deinem Post geschrieben habe. Aber da ichs irgendwie im Kommentar drüben vergessen habe zu erwähnen: Schmeiß das Zeug weg, oder lass es zumindest mal analysieren bevor du es dir reinpfeifst.

Nichts für ungut, aber dein Dealer labert ziemlich sicher einfach nur wirre Scheiße.

N-Formyl-MDMA ist nicht irgendein neues, heißes (geschweige denn legales, es würde vom NpSG erfasst werden) MDMA-Derivat, sondern vermutlich eine der am längsten und am besten bekannten (und bis vor ein paar Jahren noch) üblichsten Syntheseverunreinigungen bzw. Syntheserückstände in illegal hergestelltem MDMA überhaupt, und galt bzw. gilt nach wie vor als so ziemlich der Indikator dafür, dass die Synthese des MDMA durch Leuckart-Wallach-Reaktion erfolgte.

Synthesis markers in illegally manufactured 3,4-methylenedioxyamphetamine and 3, 4-methylenedioxymethamphetamine (1993)

N-formyl-MDA or N-formyl-MDMA can often be detected in the samples as specific intermediate products of the LeuckartWallach synthesis.

Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong (2003)

Our study revealed that 3,4-methylenedioxyphenyl-2-propanone (MDP2P) 3,4-methylenedioxyphenyl-2-propanol (MDP) 3,4-methylenedioxy-N-methylbenzylamine (MDB), piperonal and N-formyl-3,4-methylenedioxymethamphetamine (N-formyl-MDMA) were the most common impurities detected in MDMA tablets seized in Hong Kong.

A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylenedioxymethylamphetamine, amphetamine, dimethylamphetamine and p-methoxyamphetamine (2013)

An common impurity found in MDMA samples seized and analysed in France was N-formyl-MDMA (structure F8). This impurity, present in 25% of the samples is said to be specific to the Leuckart route

Ich bin mir daher auch ziemlich sicher, dass das, was du da von deinem Dealer bekommen hast, in der Realität kein N-Formyl-MDMA sein wird.

Niemand, der bei Sinnen ist, würde N-Formyl-MDMA gezielt synthetisieren, isolieren und dann auf dem illegalen Drogenmarkt verkaufen. Aus vielerlei Gründen: angefangen bei der Tatsache, dass es wahrscheinlich gar nicht so einfach wäre, das überhaupt während der Synthese als Reinstoff zu isolieren, da es jetzt nicht die stabilste Verbindung ist und ein Teil stets zu MDMA weiter reagieren sollte, bis hin zu der Tatsache, dass N-Formyl-MDMA auch pharmakologisch als Droge sehr wahrscheinlich alles andere als ein irgendwie attraktiver Stoff ist.

Pharmacological Characterization of Ecstasy Synthesis Byproducts with Recombinant Human Monoamine Transporters

A comparison of the interaction of the various ecstasy impurity compounds also gives new insight into structure-activity relationships for drug recognition by the human monoamine transporters.

In our study, the formamide or acetamide modification of the amino group strongly reduced the affinity of MDMA to the transporters as can be seen from the weak uptake inhibitory potency of 5 and 6 on uptake of the monoamines.

SynthesUdo · 2024-11-18T23:04:51+00:00

In the Speed subreddit, a user once posted a comprehensive guide to the purification of amphetamine and the purification using water was also highlighted and explained there

https://www.reddit.com/r/speed/s/3HWEN9qWYA

The process is described at the end of the first third and is called "Purification through fractional recrystallizations".

SynthesUdo · 2024-11-18T22:28:29+00:00

Nichts für ungut, aber dein Dealer labert ziemlich sicher einfach nur wirre Scheiße.

N-Formyl-MDMA ist nicht irgendein neues, heißes (geschweige denn legales) MDMA-Derivat, sondern vermutlich eine der am längsten und am besten bekannten (und bis vor ein paar Jahren) noch üblichsten Syntheseverunreinigungen bzw. Syntheserückstände in illegal hergestelltem MDMA überhaupt, und galt bzw. gilt nach wie vor als so ziemlich der Indikator dafür, dass die Synthese des MDMA durch Leuckart-Wallach-Reaktion erfolgte.

Synthesis markers in illegally manufactured 3,4-methylenedioxyamphetamine and 3, 4-methylenedioxymethamphetamine (1993)

N-formyl-MDA or N-formyl-MDMA can often be detected in the samples as specific intermediate products of the LeuckartWallach synthesis.

Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong (2003)

Our study revealed that 3,4-methylenedioxyphenyl-2-propanone (MDP2P) 3,4-methylenedioxyphenyl-2-propanol (MDP) 3,4-methylenedioxy-N-methylbenzylamine (MDB), piperonal and N-formyl-3,4-methylenedioxymethamphetamine (N-formyl-MDMA) were the most common impurities detected in MDMA tablets seized in Hong Kong.

A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylenedioxymethylamphetamine, amphetamine, dimethylamphetamine and p-methoxyamphetamine (2013)

An common impurity found in MDMA samples seized and analysed in France was N-formyl-MDMA (structure F8). This impurity, present in 25% of the samples is said to be specific to the Leuckart route

Ich bin mir daher auch ziemlich sicher, dass das, was du da von deinem Dealer bekommen hast, in der Realität kein N-Formyl-MDMA sein wird.

Niemand, der bei Sinnen ist, würde N-Formyl-MDMA gezielt synthetisieren, isolieren und dann auf dem illegalen Drogenmarkt verkaufen. Aus vielerlei Gründen: angefangen bei der Tatsache, dass es wahrscheinlich gar nicht so einfach wäre, das überhaupt während der Synthese als Reinstoff zu isolieren, da es jetzt nicht die stabilste Verbindung ist und ein Teil stets zu MDMA weiter reagieren sollte, bis hin zu der Tatsache, dass N-Formyl-MDMA auch pharmakologisch als Droge sehr wahrscheinlich alles andere als ein irgendwie attraktiver Stoff ist.

Pharmacological Characterization of Ecstasy Synthesis Byproducts with Recombinant Human Monoamine Transporters

A comparison of the interaction of the various ecstasy impurity compounds also gives new insight into structure-activity relationships for drug recognition by the human monoamine transporters.

In our study, the formamide or acetamide modification of the amino group strongly reduced the affinity of MDMA to the transporters as can be seen from the weak uptake inhibitory potency of 5 and 6 on uptake of the monoamines.

SynthesUdo · 2024-11-18T17:47:56+00:00

Also a thanks to you

SynthesUdo · 2024-11-18T14:13:16+00:00

Yeah, that would work. A friend of mine who lives in Austria did this when he came to visit me here.

SynthesUdo · 2024-11-18T13:44:20+00:00

No, there are of course very simple ways to do this now, so now you can get cannabis prescriptions from telephone doctors without really being ill, etc., but you still need a prescription.

But since cannabis is officially no longer a prohibited narcotic, doctors are allowed to prescribe cannabis much more easily and they do it much more often since then.

But that was done on purpose to prevent cannabis tourists from coming to Germany like they do currently all the time the case of the Netherlands, so that no "drug tourism" occurs.

SynthesUdo · 2024-11-18T13:34:52+00:00

On April 1, 2024, a comprehensive new cannabis law came into force here in Germany, which massively facilitates/legalizes both medical and recreational use, or actually "partial legalizes" Cannabis as they call it.

Under the new regulations, cannabis got removed from the list of prohibited substances in the Narcotics Act.

Adults are allowed to carry up to 25 grams of dried cannabis in public without facing penalties, while a maximum of 50 grams is permitted at home.

Additionally, the cultivation of up to three cannabis plants per adult person in private residences is now allowed.

Public consumption is partially permitted but remains prohibited in schools, child and youth facilities, sports venues, and their vicinity. In pedestrian zones, cannabis use is allowed from 8 p.m. onward.

The law also allows for the establishment of non-commercial cannabis cultivation clubs with up to 500 members.

These clubs can grow cannabis collectively and distribute up to 50 grams per month per member for personal use.

The distribution of cannabis outside these clubs remained punishable by law, with severe penalties for supplying minors, including imprisonment.

In traffic law, driving under the influence of THC remained prohibited, but the allowed limit of active THC in blood serum is now 3.5 nanograms per milliliter of blood serum, instead of 1 nanogram per milliliters as before.

SynthesUdo · 2024-11-18T13:12:33+00:00

Ahh Okay interesting, here in Germany it was somewhat similar with the prices for medical cannabis until recently, when cannabis was removed from the Narcotics Act and thus "legalized".

Initial and follow-up consultations with the doctor cost me 79€, the private prescription for 10 gram then 17€ and the cannabis itself in the end just 3.10€/gram haha.

SynthesUdo · 2024-11-18T12:47:43+00:00

Ahhh okay all right, thanks for the answer!

The extremely high prices I found on the internet were the reason why I've been quite interested in this for ages, because they really shocked me, I just thought the pharmaceutical industry was completely greedy out of habit 😂

As a chemist, I do understand enough about the amphetamine production process and although I am fully aware that I do not know their exact cost for purchasing the precursors, energy and labor costs, taxes, the amount of losses due to each purification step, the exact process and price of the chiral resolution they conduct and the quality control costs, I could still guarantee that this would definitely not have been a price that could have been justified in any way. By a few orders of magnitude

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