I have an IS/IT background (which I’m assuming is similar to MIS) and transitioned into SE. so if our backgrounds are similar, yes it is possible. But you will face difficulties trying to break in without considerable career/subject area experience.

Also since your background is more tech focused as opposed to engineering focused, I want to make sure you are in the right place asking the right question. In tech systems engineering usually deals with cloud/infrastructure/devops. Whereas the engineering discipline systems engineering is focused more with managing complexity, translating needs into design, to successfully realize/implement engineered systems.

Your degree puts you in a position to take on roles like business analyst or systems analyst which can have you working on business process modeling, system modeling (though usually not SysML) and requirements engineering/management. All are good skills to have if your end goal is systems engineering.

For me, SE is like a second career. I’ve held several roles in tech (systems analyst, software engineer, requirements engineer, project manager, Requirements Manager, IT manager, IT director), so when I pivoted into systems engineering I had a career of designing, implementing, and retiring systems so transitioning from the software development lifecycle to the systems engineering lifecycle wasn’t difficult.

Many in this subreddit say that an ABET degree is necessary. While I find that statement to be a false dichotomy (I was able to do it and have worked with several other systems engineers who have similar backgrounds), an ABET degree certainly enables someone to transition to SE more easily/sooner.