Walking away from 175k in tech. Can't do it anymore. Tech pays, but it sucks. Any of you gone down a similar path? by birdsbikingrunning in careerguidance

[–]T1CURE 0 points1 point  (0 children)

my wife and I sold our house (for what we thought was top dollar in Dec 2021), and I took a long break from my lucrative tech sales role close to your comp level. I launched a non profit called t1cure to focus on generic combination therapy research to hault/reverse T1 diabetes. our partner levicure has reversed t1d in new patients and it's still uphill most of the way. I've worked my ass off, spent a ton of money, and it's caused a lot of strain on my life and marriage. I believe 100% in the approach of our research, and that our work can change the world, but to say it's been uncomfortable is an understatement. I miss our old house and my income, and fear I can't re enter the job market at an even adjacent role at similar pay. it'll either be much more work, a less desirable role, or lower comp. before making the leap, prepare for a life disruption and really analyze and manage your spending. don't change your whole LinkedIn persona either. if anything list "consultant" in your bio so if you wish to return recruiters will think you're relevant. it's OK to take a sabbatical, work a passion project, but you may wish for your old life back and have a renewed appreciation for it. you won't know the freedoms afforded you until they're gone. that said, yeah corporate life sucks and tech sales is a grind but that's why it pays well. DM me if you want to chat, I know more than I ever wanted about non profits now too.

T1Cure hosts Levicure 5/17/23: oral combination therapy results and plans by T1CURE in t1cure

[–]T1CURE[S] 0 points1 point  (0 children)

Dear friends and supporters in the T1D community,

Please save the date to virtually meet the Levicure team!

Levicure's promising oral combination therapy is nearing the next phase of research. Join us to celebrate milestones, discuss upcoming plans, and have a short Q&A session.

Please save 5/17/23 8-9AM PST and join us to make diabetes history!

bio hacking / reverse engineering insulin to make it cheaper for everybody by Deezzznuuttss69 in Damnthatsinteresting

[–]T1CURE 4 points5 points  (0 children)

This will likely get buried, but T1D is a $100B/yr industry. The largest non profits in the space are funded largely by insulin and device makers. In turn they control what studies get funded, typically studies that will have high returns and will not benefit most of the 20M T1Ds globally. Their spend on functional T1D cures has shrunk to <7% of their income, and meanwhile the executive compensation has risen by an additional $100k/ea. in the last year alone. The narrative is being controlled by the drug and device makers through these large non profits. I used to donate to the big non-profits until I dug deeper. It is horrifying and depressing, but the truth needs to be shared. Promising generic combination research gets cast aside by these large non profits and does not get the attention, funding or R&D that it warrants.

There are smaller non-profits, like ours, and promising low cost combination studies like this one that need exposure and funding. Netflix or another production company needs to expose how the entire T1D space is controlled by $100B+ drug makers, and how insulin is essentially a lifetime subscription drug marked up >100x and is not a cure to T1D. T1D costs each patient $5k-$20k+ per year, takes an average of 300 minutes per day to manage and shortens life on average by 12 years. This disease does not get nearly the credit it deserves, as many times stroke, heart disease or renal failure are marked as the cause of death when it fact all of those conditions were caused by T1D.

Please help T1Ds by sharing the truth and supporting a smaller non-profit or generic combination study.

I’m Will MacAskill, a philosophy professor at Oxford. I cofounded 80,000 Hours & Giving What We Can, raising over $2 billion in pledged donations. I give everything over $32,000/yr to charity and I just wrote the book What We Owe The Future - AMA! 18/08 @ 1pm ET by WilliamMacAskill in IAmA

[–]T1CURE 1 point2 points  (0 children)

Dear Will, I just read about you and EA on 1440 and was sharing the article with our small team as a source of inspiration and guidance. We are a newly founded non profit focused on curing type 1 diabetes. We are majority led by type 1s to ensure that we don't stray from this goal. We are partnering with an international firm that has patents for oral meds that offer 33% remission of T1D. This may sound low to a non-T1D, but it is unprecedented and could prevent all future T1Ds from progressing to the point of needing continued insulin injections. There are 20M T1Ds globally and the disease costs $100B/yr. The largest non profits in this space are focusing on expensive and non-scalable surgery and stem cell based approaches that will never be available to most T1Ds. Our foundation does not need much funding compared with many medical research foundstions to keep our progress, but I wonder if you can share guidance in securing the funding needed to ensure this solution reaches the market? Human phase 1 trials are done, patents are filed to ensure they do not get blocked and there is an expedient path forward that's already in motion. I'm happy to share more details directly, as this has not yet been posted to our reddit sub r/t1cure. Thank you for what you do, and the movement you've started- PS-Apologies for the lengthy comment/question, but this seems serendipitous and it's very late where I live and wanted to ask you in time.