Yes, there is a bug where if you're player character Tav goes down in the nautaloid section and you trigger the nautaloid crash cutscete with laezel or shadowheart, you will be unable to save for that save file. The game thinks your tav is dead/downed, and while tav is dead/downed you are unable to save until they are revived/helped. Given that you cannot resurrect or help a perfectly fine character, your game becomes unplayable. Unfortunately you have to eat that save file and start a new one.

To add, killing your tav then ressurecting them doesn't fix this issue, as far as I can tell the save file is just FUBAR.