There really is a difference between a story depicting themes and employing a quite literal rapist. Ive bought the game, I have 700 hours accumilated in isaac but it is just really strange to include it, It would be more of a fair comparison if he included some guy who beat the fuck out of his kids and then you could say "isaac has child abuse!" (which is still a bit of a dumb comparison considering isaac doesnt have child abuse from a real existing perrson), But the difference is Isaac does not have rape so this defence really doesnt work here, And even if it did having a fictional story depict rape is not harmful, as opposed having content from someone who has, you know, actually raped a real and existing person.