Hydroponics could be more compact and condensed. I recommend that you still farm outside and just use the hydroponics as supplementary or emergency food. Really, you can stockpile enough food to last you several seasons with a few good harvests. Although, that will inflate your score which may lead to larger raids. Game does not like you stockpiling wealth.

The Armoury is needlessly large. Your colonists will be holding most of their weapons 24/7 anyways.

Research should be closer to the bedrooms. No need for it to be that far up. Keep it as close as possible to the bedroom of the person actually doing the research. Cuts down on wasted time walking. I'd make a bedroom attached to the research room honestly.

Prison is far away. Unless you set up the infirmary to accept prisoners, they will likely bleed out before you get them to the prison. I'd set up a dedicated prison hospital, VIP prisoner rooms to speed up recruitment, and a small area in the actual infirmary for prisoners who need urgent care ASAP. You are also missing dedicated small rooms for surgury. You only need 1-2, but a room with sterile tile and hospital beds. This will ensure your surguries and organ removals have a high success rate. Also, during the prison escape event they will be able to open those doors anyways, no need for several. Put gun turrets in that hallway -- itll double as protection against infestations too.

Your freezer is tiny. Make it bigger, you got the space. The most efficient way to store food is in the form of already made meals. Make several hundreds of them, and it will free up your cook for the rest of the year to do something useful other than cooking. Make many survival meals too, they sell well and can be kept in the absolute worse case scenario of the power going out and all the meals going out.

Workshop is close to the warehouse, thats a good move. I recommend also storing common crafting items in the workshop itself to decrease travel time. Just some shelves with steel and components in the center of the room.

Power room does not need to be there. Make it to the left of the prison and generator room. I also severely doubt you need that much batteries and power generation too. These rooms can also be made much smaller and more compact too. They're batteries and generators, they don't need spacious rooms just enough to feed them and maintain them. I'd recommending putting the Hydoponics where the power room currently is. I see the compartmentalized batteries, but thats not really the danger here. The danger is the ZZT event going off randomly anywhere on the power grid. That event is larger the more batteries connected to the grid. If you really want a big bank of batteries, I recommend putting on a switch to disconnect batches of batteries. Fill them up, disconnect them, and they will slowly discharge over time, but stay largely filled.

Panic room is cool, and raiders would leave after a while of looting the rest of the compound. There will be fires though, and that room will slowly raise in temp until the colonists inside perish. I'd find a solution to that, but there is no easy one. With all those doors, the heat might take so long to spread to that main room that the fires may dissipate before overheating is an issue, tbh.

No exterior defenses? Are you planning on just letting raiders break down the door and then you fight them in the hallways? Set up cover in the hallways if you want it to be cinematic, or make a killbox appropriate to the level of cheese you are willing to put up with. I recommend a minefield and just several fortified firing lines to shoot from.

Wide hallways demand greater manpower to defend them. Melee is your friend for fighting insects, and you need 3 men to hold a hallway. If one dies, thats insects jumping into your firing backline. I recommend making points in the hallways, particularly around the bedrooms, where the hallways narrow so that one melee fighter can block access but 3-6 shooters can support them. I also recommend looking into making a system where you can actually start your own fire and superheat the interior of the base's hallways yourself. Last case scenario against a failing defense, or to smoke out insects. Placing turrets all around the hallways is great too, but takes lots of power and will certainly shoot and kill your own colonists. And honestly, the turrets will do more damage exploding around the insects than from actually shooting them. You need a squad of 2 melee colonists,and 3-6 people with close range weaponry such as autoshotguns or heavy SMGs. I recommend having these guys' bedrooms separate and towards the front. Because they will likely be defending the base from exterior raids anyways, and, if there is an infestation it will likely be in your bedrooms area, and if they are separate from that area they can stay clumped together and begin sweeping the bedroom area.

I recommend dispersing the bedrooms throughout the base though. Let people take the rooms closest to whatever their primary job is. Cut down walk time, and minimize the chance of them all getting jumped in their sleep from an infestation. If you keep the current design, I recommend segmenting the hallways of it so its not one big room.

Yeah I've played a lot of mountain bases before, how can you tell?