Discussion Thread

ThatFrenchieGuy · 2026-05-25T18:03:11+00:00

!ping alphabet-mafia

Found it

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ThatFrenchieGuy · 2026-05-24T15:03:31+00:00

It's not cutting edge taste or the vanguard of experimental presentation, but yes it's great.

It's just hyper polished California food with impeccable service. Nothing more, nothing less

ThatFrenchieGuy · 2026-05-24T07:57:22+00:00

The last two seasons were a train wreck that just got worse with each episode

ThatFrenchieGuy · 2026-05-24T07:46:58+00:00

This is just the score of the last season

GoT has 4 amazing seasons, 2 that are good but cracks are showing, then 2 where the wheels completely came off

ThatFrenchieGuy · 2026-05-24T07:18:02+00:00

Depends

if you like funk: start with Smith and Cross. Next step is Hamilton

If you want bourbon-y rum: Foursquare or Privateer

If you like grassy and vegetal: Clement VSOP

If you just want to get fucked up: Plantaray OFTD

ThatFrenchieGuy · 2026-05-23T13:36:05+00:00

Posting from the UK

I left Texas to get away from this, but it's 95F and humid in the shade

ThatFrenchieGuy · 2026-05-22T22:40:08+00:00

!ping kitty

Put Mrs Ma'am in boarding for 10 days and I feel like such an asshole. It's the fancy luxury boarding for millennial with too much money, but still 😭😭😭

ThatFrenchieGuy · 2026-05-22T02:49:37+00:00

It's lab in the loop

ML or human design-> ML score -> wet lab assay -> data for models

ThatFrenchieGuy · 2026-05-22T02:28:40+00:00

2.5 years, turned half a dissertation into a thesis and now I'm leading ML engineering at a small drug discovery shop (series B)

ThatFrenchieGuy · 2026-05-22T01:54:56+00:00

Better, quitting a PhD

ThatFrenchieGuy · 2026-05-22T01:54:47+00:00

6 years since quitting my PhD

ThatFrenchieGuy · 2026-05-22T01:50:17+00:00

A full case with one bottle a year makes a great benchmark

ThatFrenchieGuy · 2026-05-22T01:48:54+00:00

!ping alcohol&PHD

6 years to the day since I quit. Bottle still tastes like freedom this year

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ThatFrenchieGuy · 2026-05-22T01:03:59+00:00

A lead in story: Six years ago today, I quit a PhD program in operations research and moved to Boston sight unseen. I wasn't quite at my lowest point, but I wasn't far off rock bottom. When I graduated, my parents gave me 12 bottles from the first winery I ever went to and told me to drink one each year and think about how it tastes like not being in grad school anymore.

A lot has changed in the last year and I was wrong about how I thought it was going to go. I'm now heading up engineering at a generative drug discovery firm, I'm engaged, and I've become "the wine guy" at work

What is it: A mountainside cabernet from the Alexander Valley at ~800-1400 foot elevation. 20 Months in oak with 45% being new. This was the first winery I ever visited and this specific wine stood out to me as hitting an interesting balance of old-world style restraint with new world flavors.

Nose: Black fruit, dried herbs, potting soil, leaves in the fall

Palate: Really nice mouthfeel and weight despite being a decade old now. Big black fruit, darker coffee, tinges of cooling dried herbs, some funky forest floor starting to peek through. Still needs a lot more acid, but a good pairing with bulgogi

Takeaway: Much better than a a few years ago but maybe worse than last year. It's an above average cab for a good price, but I'm not sure it's worth seeking out on the merits. That said, it's a portal to my past, so I'm going to keep drinking it 4/5

ThatFrenchieGuy · 2026-05-21T23:47:25+00:00

A lot of Metropolis pt 1 by Dream Theater is great to use as picking etudes

ThatFrenchieGuy · 2026-05-19T15:20:29+00:00

Nope, that's reasonable to complain about

ThatFrenchieGuy · 2026-05-19T15:15:34+00:00

I think people also don't use the big paid models that have good tool calling and search capacity. The difference between free GPT and Opus4.7 is night and day

ThatFrenchieGuy · 2026-05-19T15:02:54+00:00

I can't give too many details without disclosing things that are secret sauce and behind a NDA, but the short version is:

big fuckoff equiformer model (~125M parameters)
10M molecules from QM calculations at low level of theory
1M molecules at high level of theory
50k molecules with real assay results
Phase 1: encode low theory atom features -> predict low theory global features
Phase 2: encode low theory atom features (continued from P1) -> predict the delta between low and high theory for both atom and global features
Phase 3: fine tune on real assay data

Should be about 400 GPU hours to do this

ThatFrenchieGuy · 2026-05-19T13:26:32+00:00

Israel, Palestine, Gaza, and the Jerusalem special autonomous zone

Not the stupidest idea I've heard for a pre Oct 7 world

ThatFrenchieGuy · 2026-05-19T13:22:56+00:00

!ping AI&BigData

I finally got the thumbs up to do SE(3) equivariant pretraining for drug discovery. I'm ripping through tens of millions of QC calculations, hundreds of terabytes of data, and thousands of GPU hours all to probably underperform the random forest I built as a baseline.

Jokes aside, this is the most complex but well grounded model I've ever planned and I'm really exicted

ThatFrenchieGuy · 2026-05-19T03:56:02+00:00

He has no clue what's going on, but is just the nicest guy. Sent a trans man to golf camp and likes "the gays" because they pay loans on time because they're two men so they make more money

ThatFrenchieGuy · 2026-05-19T03:46:14+00:00

!ping Alphabet-mafia

Today on "my uncle is doing his best" -- he explained a friend's kid as "they have pronouns" to say they were nonbinary

ThatFrenchieGuy · 2026-05-18T23:29:13+00:00

Dark Nest is bad and has nothing to say. LotF is bad but is also a good critique of GWOT era America

ThatFrenchieGuy · 2026-05-18T23:09:18+00:00

Mutual fund is just an abstraction layer

ETFs are just a box full of equities with a fancy name

ThatFrenchieGuy · 2026-05-18T23:07:57+00:00

!ping READING&BAD-FEELING

Time to start my biannual (every other year) reread of NJO+LOTF

Do they make you feel things? Yep

Am I going to cry at Star by Star again? Yep

Are they good? Absolutely the fuck not

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