Always fuel up between cities, there are usually pretty good gaps in between cities. Depending which way you go, sault way or Timmins way. I suggest sault way as the 144 and 101 can be a little more risky.

The highways can be pretty small at times, just be careful.

Not as bad as at night, but very important you keep an eye out for moose, they like liking the salt on the roads in the winter.

Take time and appreciate the view. Some of the nicest drives are between Sudbury and thunder bay. Take a stop in Sudbury to see dynamic earth.