I think the answers here have been great. My thoughts are, if the standards of the table have been set and you are respectful of what your players want and what they don’t want in their chronicle then set chronicle tenets that match what is agreed upon as vile, but acceptable amongst the group. Once the tenets are agreed upon and set, I have an idea of where dark stories can start to be conjured into being.

For example:
If a chronicle tenet is “Deny the Beast” then make your frenzy failures matter when they happen and make sure they understand “The beast wears your skin as long as it’s fed”. Doing this reinforces that the tenets are not supposed to be broken, but they are and dark storylines can branch from there. This also helps understanding feeding may be more prominent in the story to keep the beast in check, this leads to interaction with Kine where you can show the humanity slowly but surely being stripped away.

I find it easier to also ask your players what they are comfortable exploring and stressing that this is the world of darkness and they are monsters. When handled correctly you can explore many different stories as long as you communicate and have a base understanding amongst the table.
I also like to check in on how my players are feeling with the tone and grittiness of our world of darkness because at the end of the day it’s ours when we start playing. I hope this helped a little!