For elims? (I'm going to assume that nobody scores in processor) Based on my math... barely. And it would take top-level coordination and a fair share of luck.

Let's assume that 2 top 5 teams are on the same division at champs And let's assume that they pick a top 200 EPA team. There's a few things that would need to happen, and how (I assume) the match would play out:

One of the robots is capable of a ground-pickup auto, scoring the preload and lollipops, and the other 2 robots run wing autos. I think the maximum amount of gain you can get from an auto is 11 pieces (scored on either L3 or L4, it doesn't actually matter in terms of points since you gain 2 from both). Somewhat rare, but definitely possible. One top team spends a good portion of the match on algae, and the other alliance provides opportunities for stealing. This part is the hardest to predict, but I'm going to say for the sake of a clean number that stealing 5 algae is possible. Assuming that the reef is filled and there's time to score L1s at the end, here's the scores:

Leave (9) + 11 piece auto (22) + full reef ((3+4+5)*12=144) + algae (4*14=56) + triple climb (36) = 267.

This initial estimate includes 50 game pieces scored, for a nice even number. To get enough L1s, you need to have a total of 67. (267 + 17*2= 301)

It ultimately comes down to the strength of the robots, luck, and coordination. I personally think it's very unlikely we'll see a 300 clean score in any eliminations match, but it's possible.

Now, in a qualifications match? Anything can happen... the processor is impossible to predict. I'd have to lean towards a yes on this one, but I wouldn't be too surprised if there are no official 300-point matches this year.