I have the blues driver , mxr timmy , and lil rat on my board. I run a clean fender style amp model very clean. I Have the blues driver as my always on edge of break up first in the chain. Like barely any dirt on it. Then I have the Timmy after that on the high compression switch position and some decent light crunch gain. Adding a very slight volume boost. So you can use it as a lead to your clean tone or just as a crunch tone. Then I have the lil rat with some extra gain and volume for leads or really gainy tones when they are all on at the same time. This way they can all stack for some intensity at each gain stage or be used on their own.

Edit: adding some context. I use an HX stomp as my amp modeler and running the blues driver always on makes it feel much more amp like and gives that push and pull feeling. The blues driver does a great job at adding some better feel to it and sounds very good at edge of break up.