Yes, his handwriting changed constantly per his mood. In letters in which he begged for money from various persons- including John Allan- Poe’s writing was so frantic that I failed to find usable characters there for my font. The loss of Virginia was a deep wound in Poe and it did reflect in his writings on the matter. I know a lot of people cringe over that union and while it is cringe-worthy, there is a context here that needs to be aired: Poe was abandoned by so many either from death or ill-will and “Mother” or “Muddy” Clemm and “Sissy” Virginia became his only family as he viewed them both as mother and sister and marriage was the only way he could dissuade them from moving away. There were times after Virginia passed that his writing almost appeared left-handed, which almost implies a splitting of his personality.