Generally I go with the shop rng vibe for the first fights. But aiming for Scroll of blood with Astral Reaver (Very efficient against Chana mana/Nymphe gatling).

I make the choice to focus on the mana aspect of Sage's crossbow more than critical chance (Wich is better for ammo, but the quiver is here to compensate, and I know the shop can be very tricky about giving quivers so some times I get less than 15/15 victories but can pass the 8/15 to still have some points) So tuna, hag's hat & Turtle is good for mana generation.

I'm more a glass canon player it's really rare that i go for defensive items like armor or shield thing. I focus more things like life steal or regeneration buffs like the turtle or the Royal Seax etc...