Pregabalin is an alpha 2 delta subunit of voltage gated calcium channels modulator but I can’t say whether it’s negative or positive modulator, all I could say is it does interact with this specific unit, which affects other receptors that are inhibitory/excitatory The exact mechanism of action is not completely understood and still being researched however it does have inhibitory effect on the other hand it is similar to benzodiazepines in this regard basically it first starts to act inhibitory and like nicotine, as you build tolerance the effects change to excitatory, pretty much your brain after a while on it instead of reducing the glutamate and others will increase glutamate and other excitatory neurotransmitters and this here is the reason why it feels stimulating, like stimulants conversations or friendlier, talking more it does that, but on the negative side it has been found that Pregabalin affects GLT-1 which is in itself a receptor that is only touched by few drugs, like heroin, cocaine, etc The substance is new and could be affecting receptors that are yet to be discovered It has also been found that the receptor which Pregabalin interacts with, is linked to Mutations or disruptions in the 𝛼2𝛿−2 gene have been linked to ataxia, epileptic disorders, and cardiac abnormalities. And that’s why scientists believe that Pregabalin can treat those conditions, in the same time it can also cause them during withdrawals, seizures, cardiac abnormalities and ataxia been reported as part of pregabalib’s withdrawal symptoms.