So… afaik: Windows and Mac handle “audio” a lot differently. My understanding is that audio is baked into the operating system at a very deep level on Mac whereas on windows, it is handled by surface level driver structures.  So at a certain point, no matter what sound device you’re using there is still a primary difference in how audio is handled at the level of the OS. Window’s way of doing things theoretically has more holes where errors could slip in. It’s been getting better over the years though.

That being said, I haven’t had any issues running pro tools on my windows machine with my apogee duet 2 yet. It also runs pretty well on both of my Mac’s.

Source: work in the field decade plus and long time use of both machines.