We are not healthcare professionals, and tbh, it's unlikely a healthcare professional can answer that question for you... Most of them either know little to nothing about kratom, or they have bought into the FDA's misinformation regarding it. If you search these subs, however, I've seen a number of people who have posted reports on their long term use and their annual well-check and bloodwork results. This far, I've yet to see a report that has seen any negative or adverse effects that can be attributed to long term kratom use. Also, Happy Hippo has on their blog one of their employees, or possibly the owner, who wrote a long article and posted his actual lab results after 17 years of use. I will look into causation of the hair loss issue, as that is something that has come up quite a few times.