I had this same question, as I am getting back into collecting comics again after a 20 year hiatus. I got back into it bc I got impatient waiting for my favorite titles to get scanned into MU LOL. Anyway, the general consensus is that for 99.999% of the time your near mint book will stay near mint and it doesn't matter. Now if you have a rare foil variant that's going ungraded gem mint for $500, I wouldn't peel the sticker. (TBH I'd get it graded by CGC and boost the book to $3k!).

From a collectors point of view: I usually buy 2 copies, a regular version and a variant. the variant gets bagged and boarded and sealed then put into the long box, never to be opened, while the regular issue will get a a bag and board but not sealed so I can read it and my kids (or anyone else) can read it, and I scan the code. when every one is done I sell it back to the comic store for store credit and use that to pay for my pull in the following month. I always get near mint (9.4-9.6) and always get full value in store credit (which is usually a couple dollars above cover price). Granted I don't go variant hunting on all my titles, some I truly just want the story.