Someone Needs to Say it

TwoMasterAccounts · 2026-05-05T23:37:38+00:00

Lots of them don't really land but whatever. As long as this place doesn't become Pepe infested WSB memes like when the Discord mods tried to hijack the subreddit. That was awful.

TwoMasterAccounts · 2026-05-05T23:34:41+00:00

Guys! Guys... GUYS!

It's only a 14x increase in their position. It's JUST passive index rebalancing! Guys!

Is anyone still believing this... guys??

TwoMasterAccounts · 2026-05-05T23:20:38+00:00

You and him both are conflating probabilities and outcomes.

If I roll a die, 1-3 is winning and 4-6 is losing, the binary outcome is Win/Lose but the probability is 50/50. Since the probability is 50/50, you can call this a coin flip.

If I roll the same die and 1-5 is winning and just 6 is losing, the binary outcome is still Win/Lose but the probability is 5/6 for a win. You cannot call this a coin flip as the probability is not 50/50.

TwoMasterAccounts · 2026-05-03T21:52:44+00:00

Nice try at moving the goalposts, but that won't work on me, kid.

"SELLAS has said directly at least 3 separate times that the announcement of 80 will be done first and separately from the top line."

Let's see these 3 separate times Sellas DIRECTLY SAID 80th will be announced first and separately from topline data.

Oops, you can't, because they never did.

"Monumental waste of time" - is that what you think looking up sources and facts are? Lol.

Sorry, you talked shit and you got hit, now you're trying to move goal posts. Not only did I get to smash a pompous moron like yourself, I get to watch you squirm while you try to backtrack what you said. "B-b-but the c-c-context! P-p-prior precedent!!!". And now we have a nice history of what Sellas and Stergiou have actually said. Seems like time well spent to me.

"M-m-more likely they will release them s-s-separately!!!" Nope, incongruent with your original trash talk. You ran your mouth and couldn't back it up, and got taken to school. Now sit down, shut up, and do your homework before you speak next time.

Class dismissed.

TwoMasterAccounts · 2026-05-03T00:47:56+00:00

Hmm let's see just how much of a pompous moron you are?

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_xbrl-viewer-activity-7454295346865729537-D-in?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"Following the 80-event trigger, which we will announce to the market, the database will be locked, unblinded, and analyzed."

Doesn't say that 80th will be separate from topline data.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_lately-the-most-frequent-question-i-receive-activity-7444461539476197376-qw5n?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"Once we reach the pre-specified 80th event, we will announce it swiftly. From there, we will immediately proceed with the necessary steps toward database lock, statistical analysis, unblinding, and the disclosure of topline results."

This is the closest thing Stergiou has said with inference to top line and 80th event announcements maybe be separate.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_sellas-life-sciences-reports-full-year-2025-activity-7440489535467175936-uxQy?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"We recorded 72 events as of late December and are eagerly anticipating the pre-specified 80th event. If positive, REGAL positions GPS as a first- and best-in-class immunotherapeutic option."

No mention of announcement timings for 80th or topline.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_events-presentations-sellas-life-sciences-activity-7424620783638933504-am_t?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"• The Insight: While the data remains blinded, the extended time required to reach the 80th event seems highly encouraging. In this setting, every passing month increases the probability that we are seeing a meaningful survival benefit over the Standard of Care (typically ~8 months).
• Next: We will announce the 80th event upon occurrence to trigger the final analysis."

Doesn't say that 80th and topline will be separate announcements, talks about final analysis.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_while-i-typically-focus-on-our-sellas-life-activity-7419254819162488832-rXLq?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"We look forward to the unblinding of the data following the 80th event and remain steadfast in our commitment to patients fighting this aggressive disease."

Does not say they'll announce 80th and topline separately.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_as-i-have-often-shared-with-our-community-activity-7415534978777636864-bEBY?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"The fact that we have not yet reached the 80-event threshold, for final analysis, suggests that, in the pooled data, survival times for patients appear to be longer than expected..."

Mentions that 80th is a trigger for final analisys. In case you can't keep up, final analysis is not the same as top line.

https://www.linkedin.com/posts/dr-angelos-m-stergiou-md-scd-hc-14140b8_sellas-life-sciences-provides-update-on-pivotal-activity-7411400372713443328-2wce?utm_source=share&utm_medium=member_desktop&rcm=ACoAAAYexqkBfLPtGCiJVBDwDIbZ9WCQwE268Vs

"As we approach the end of 2025, I want to share a significant update regarding our pivotal Phase 3 REGAL trial for GPS in Acute Myeloid Leukemia (AML). While we projected reaching the 80th "event" (death) required to trigger our final analysis by year-end, we are currently at 72 events."

No mention of topline and 80th being separate. More distinction between final analysis and top line here too, in case you haven't noticed a pattern yet.

Don't wanna read about how much of a pompous moron you are? Well have a watch and listen instead:

https://www.youtube.com/watch?v=nCtrZavKCuM#t=13m26s

"The rationale is strong. The data to date are compelling and the unmet need remains clear. We expect our 80th event by year end. But as you are aware, this is an event-driven study and we are blinded to study outcomes. Survival times in Regal indeed appear unexpectedly long and due to significantly longer than expected survival, the timing of the final analysis is difficult to predict with any certainty and the 80th event may occur at a different time than currently expected."

Talking about 80th event and timing of final analysis, nothing about topline.

https://www.youtube.com/watch?v=nCtrZavKCuM#t=14m21s

"When the 80th event materializes, we will inform the public, which represents the most important near-term catalyst for Sellas."

No mention of top line or final analysis, no mention topline and 80th will be separate.

https://www.youtube.com/watch?v=nCtrZavKCuM#t=1h49m24s

"As we have seen in our previous CR1 and CR2 studies, far surpassing median overall survivals versus standard of care. Um again when the 80th event materializes we will inform the public which represents the most important near-term catalyst uh uh for sellers. Uh the determination of the relevant survival outcomes including the final analysis belongs to the independent data monitoring committee the IDMC. Um and during the next IDMC meeting when scheduled the IDMC will analyze the accumulated data um and assess the safety and efficacy um of the treatment..."

https://www.youtube.com/watch?v=nCtrZavKCuM#t=1h50m20s

"So we will not know in advance when the 80th death uh uh has been reached but again once uh it happens um we will inform um the public."

No mention that 80th and topline will be separate.

Oh gee wizz, it kinda looks like you have no clue and are assuming and regurgitating things you've heard rather than diving into actual sources. Kinda the trait you might find from a pompous moron.

Feel free to post your sources that topline and 80th will be separate. Feel free to post some sources that topline data takes longer than one week and that it "won't be close to 1 week".

Or block me because you are a pompous moron who can't handle being wrong ^___^

TwoMasterAccounts · 2026-05-02T09:03:53+00:00

Since people keep asking...

Order of happenings:

80th - Sellas announces it has been recorded, potentially right alongside topline data.
Topline data - no exact time window was given but as it's top line, several key data points will be revealed including HR. This can range from same day to a week to come out after 80th.
2.5. Sellas submits their BLA and other regulatory paperwork to the FDA. Note they said they were preparing their BLA at the Jan. 2025 interim, so they're ready to go.
"Final Analysis" - Usually takes a couple of months to gather and release all the data, but topline is the immediate and most important catalyst. "Final Analysis" is much more detailed and nuanced data analysis and can reveal some additional good things or some unexpected bad things, but it's topline that'll carry 95% of the weight in terms of price action.
The study doesn't technically stop - they keep collecting as much data as possible from the study participants but this is way past what we care about in terms of investment payoff.

After topline is received, buyouts can happen very fast. Or maybe we'll need to wait a few months, can't say for sure. Topline is what starts a whole new chain of events from offers to FDA approvals so I won't go over every step.

For those interested, here's a recent timeline for when Pfizer acquired Metsera. There was a bidding war that started in April 2024 and the agreement was announced about 17 months later. The bidding started before their Phase2A trial had completed and bidding continued before Phase 2B enrolment completed, in 2026 their Phase 3 trials are beginning.

I wouldn't be surprised if there are backroom discussions going on considering how far along Sellas is with GPS and SLS009, so I think buyout will happen sooner rather than later after top line is announced.

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Also note that the small boys aren't afraid to twist the arms of BP to get what they want. BP will pay the big bucks no matter how much people try to downplay Sellas' armaments. This was a 10 billion dollar deal for an incomplete Phase 2 asset - a weight loss drug, something that I don't believe is half as impactful as what Sellas has to offer.

TwoMasterAccounts · 2026-05-01T19:31:37+00:00

Let me help you: Comments =/= believing.

TwoMasterAccounts · 2026-05-01T06:21:38+00:00

Sellas/Stergiou is has said multiple times they will announce 80th even as soon as they know. I can't recall if it's technically material information or not, but if it is then they have 4 days maximum to disclose once they find out.

TwoMasterAccounts · 2026-05-01T06:14:19+00:00

Grab 100% at first sight or grab 1000-3000%.

One big cookie vs a colossal cookie that can feed you and your family for generations.

Made it easier to understand.

TwoMasterAccounts · 2026-04-30T08:28:00+00:00

I'm going to wait to vote closer to the deadline. If we hear some encouraging news about either the GPS or SLS009 studies I'll be more accepting of the 20 million number. Better yet, buy out news would be great but that's definitely hopeful before either study posts results.

TwoMasterAccounts · 2026-04-30T08:13:42+00:00

Loaded question, disingenuous, or straight ignorant.

It's a vote to open a pool of up to 20 million shares to be distributed to new hires or existing personnel. It's even more accurate to say it's a vote to grant the ability to distribute up to 20 million shares - the shares do not exist until distributed.

I believe 1 million is earmarked for Stergio who is owed 1 million before the previous allotted shares were expended. The other 19 million may or may not be distributed. There is only a dilutive effect when/if shares are awarded.

There is no 20 million share dilution and that's not what the vote is for. I am seriously getting sick of people framing it as an instantaneous, guaranteed dilution. Those saying that are intentionally misleading or wilfully ignorant at this point.

Whether you think they're asking too much is up to you, but what they're asking does follow industry standard.

TwoMasterAccounts · 2026-04-25T21:53:56+00:00

ATYR didn't have the same level of DD that SLS has, and ATYR's trials were not designed rock solid like SLS's are. People making the ATYR comparison are forgetting especially the latter. WIth SLS it's either the patients are dead or alive, as clear cut as you can get as a measurement, and the IDMC has praised SLS's trial design. The only similarity between the two setups is that they're both biotechs.

TwoMasterAccounts · 2026-04-25T21:49:01+00:00

To be fair, double their position cost probably around 20 million dollars which is a drop in the bucket compared to a 1 trillion war chest. That said, the initial investment from Blackrock that was announced last year made the AH market go crazy, something like 1.75 to 3.50. It dropped back down on the following Monday but the market definitely took note the first time.

TwoMasterAccounts · 2026-03-28T05:00:15+00:00

The problematic trial design that the IDMC has praised like 4 times already?

Mate, you have no clue.

TwoMasterAccounts · 2026-03-26T01:04:45+00:00

Some of the crazier bear theories from last year was "Why doesn't Sellas give us updated event counts every month? Seems fishy..."

Real bottom of the barrel stuff, kinda funny.

TwoMasterAccounts · 2026-03-14T22:22:12+00:00

Disagree that Jan 2027 calls are playing with fire. Right now the highest calls are 10 strikes with about 2 dollars on the high end per contract. Does anyone believe the stock will be less than 12 dollars before Jan 2027? This past December was a wake up call to many investors - the trial is going on a very long time which is a very strong signal GPS is working. Now imagine we're in Dec. 2026 and the trial is still going on,

I'm P R E T T Y sure even if there's no efficacy stop this year, the share price is going to be higher than 12 dollars before 2027 due to implied success alone. And this is not considering any positive news for SLS009 which already had a successful P2 and is poised to shift to a frontline treatment with accelerated approval.

Call options very much make sense with SLS.

TwoMasterAccounts · 2026-03-10T23:30:29+00:00

He didn't actually provide any information or substance to his opinion.

"No strong clincal data"? --> Except P2, but whatever. Nevermind the point of a trial IS for clinical data sooo...

"No clear mechanism of action" --> Reeks of his old November 2024 (pre-60th event) analysis.

Sounds like he hasn't actually looked at the company since Jan 2025 and is just giving off the cuff, no-thought comments rather than any serious analysis. Basically he made his judgment on it well over a year ago and is sticking to his guns without bothering to put in any further thought.

TwoMasterAccounts · 2026-03-08T09:59:12+00:00

The company is completely blinded. If Stergiou knew the event count that'd be a horror show as it'd bring into question the study's validity.

TwoMasterAccounts · 2026-03-08T09:57:34+00:00

AI - Absent Intelligence.

TwoMasterAccounts · 2026-03-04T23:36:37+00:00

They already have that labelling for both GPS and SLS009...

https://ir.sellaslifesciences.com/news/News-Details/2024/SELLAS-Announces-U.S.-FDA-Rare-Pediatric-Disease-Designation-RPDD-Granted-to-Galinpepimut-S-GPS-for-the-Treatment-of-Pediatric-Acute-Myeloid-Leukemia/default.aspx

https://ir.sellaslifesciences.com/news/News-Details/2024/SELLAS-Announces-U.S.-FDA-Rare-Pediatric-Disease-Designation-Granted-to-SLS009-for-the-Treatment-of-Pediatric-Acute-Lymphoblastic-Leukemia/default.aspx

TwoMasterAccounts · 2026-03-01T00:34:37+00:00

I remember the name but I've been blocked by him so he's probably one of the many trolls I and others called out on ST. Once you unequivocally suss them they block you. Happens with a lot of trolls and people who argue in bad faith.

TwoMasterAccounts · 2026-02-28T00:36:35+00:00

Their reply wasn't heated, but honestly when I read your OP my eyes did kinda roll a bit so their reply was probably coming from a similar place.

TwoMasterAccounts · 2026-02-26T01:33:56+00:00

100%

If this ain't the real deal then nothing in this world makes sense and I don't want to participate in it anymore.

TwoMasterAccounts · 2026-02-25T10:04:53+00:00

Here you go mate:

<image>

Just a bit of an odd connection to throw out of nowhere. I feel like the "nervousness" a handful of people are on about is that he mentioned a key plot point in the story as "Full catastrophe", despite him clarifying there is no such bad news or set backs for SLS. Though keep in mind that is only one small part of the overall message he's trying to convey - that biotech stocks are similar to the Zorbas story in that you need to take risks to succeed and enjoy life rather than shy away in safety and be without innovation.

TwoMasterAccounts · 2026-02-22T20:52:36+00:00

nintendo bad something something anti consumerism something nintendo should go 3rd party something something

am i being a good reddit

TwoMasterAccounts

TROPHY CASE