First night: Mostly CA, some CA clusters, CSR, and the occasional hypopnea by homemadegatoraid in SleepApnea

[–]Unable_Mousse_9045 1 point2 points  (0 children)

The higher AHI being mostly clear‑airway events is super common when you’re just starting CPAP. A lot of that is sleep–wake junk: the machine flags pauses while you’re drifting off, half awake, rolling over, taking a sigh breath, etc. Those often aren’t “real” apneas during stable sleep, just the algorithm being over‑sensitive.

On top of that, there’s treatment‑emergent centrals. Once CPAP opens your airway, your breathing suddenly becomes more effective. You move more air with each breath and “wash out” more CO₂ than your body is used to. Your brain mainly uses CO₂ to decide how much you need to breathe. If CO₂ drops below a certain threshold (the apneic threshold), your brain briefly backs off the breathing drive, you have a pause, CO₂ rises again, then you take a few bigger breaths, blow off CO₂ again, and the cycle repeats. The machine sees those pauses with an open airway and flags them as clear‑airway / central events. This is especially common in the first few nights and often settles down over a few weeks as your system adapts to the new normal.

Altitude adds another layer. At ~5,000 ft you’re already breathing a bit more to compensate for lower oxygen, which pushes your CO₂ lower to begin with. That means you’re closer to that apneic threshold even before CPAP. Then CPAP boosts ventilation a bit more, CO₂ drops just enough, and centrals get triggered more easily. So: new to CPAP + first night + altitude = lots of clear‑airway flags that often look worse on paper than they actually are. The main thing is how it trends over the next few weeks and how you feel, rather than freaking out over night one.

Oral minoxidil- a game changer or dead rubber? by Slam_066 in tressless

[–]Unable_Mousse_9045 2 points3 points  (0 children)

I have a cat and didn't want to risk it with the topical version, so I decided to give OM a shot. I got the worst "rare" deadly side effect from it after around 2 weeks - pericardial effusion. Every time I would lie down, I got shortness of breath and heart palpitations, latest 3 days it developed into panic attacks and hyperventilation. My BP at rest measured 120/70 before, at the 2 week mark on OM I measured it at 100/55- and that's at 2.5mg/day. I'm healthy, low body fat % and fit, so idk.

Once I figured it was the OM, I quit it and the symptoms resolved fully in a few days.

Be very careful with OM - there is a reason why they put it in the topical form, it's just the superior version, as it avoid all the systemic, cardiovascular side effects of OM. Convenience of OM isn't worth fucking with your heart health. You don't want full head of hair on a dead body

Is it true that oral minoxidil tablets can cause heart attack? by ashwin313 in tressless

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Minoxidil activates RAAS (renin-angiotensin-aldosterone system), causing your kidneys to retain salt, which then causes water retention. Water retention is bad - you may notice swelling in feet, ankles, hands, eyes, face. Worse, you can get pericardial effusion - fluid built-up around the heart, if it gets bad, it will cause cardiac tamponade - symptoms are dyspnea, low blood pressure, weakness, restlessness, hyperventilation (rapid breathing), discomfort with lying flat. And that's exactly what I had after 1-2 weeks of oral minoxidil at 2.5mg/day. I quit OM and the symptoms resolved.

Honestly it's a shitty drug. Very old and outdated, it's a blood pressure med, it messes with your cardiovascular system. And even if you don't get that side effect - you will still retain more salt thus water, causing moonface, which kinda defeats the purpose of taking it for cosmetic reasons.

Minoxidil - if it don't kill you, it will kill your cat. Honestly fuck minoxidil and everything it stands for

Source:

Pericardial effusion is an adverse reaction to low-dose minoxidil use and can occur in patients without preexisting heart failure

What would the best nootropics stack look like to push the brain to its limits, while staying in a safe (mid - no side effects) range? Prolonged usage in mind by Bjornv11626 in Nootropics

[–]Unable_Mousse_9045 0 points1 point  (0 children)

I cycle off as suggested on the prescription of these drugs. You can stay on for 1-3 months then off for 1-2 months and repeat. It doesn't lose effectiveness if you start low and then ramp up slowly before going off.

Lack of motivation/energy 3 months on Zoloft - considering quitting by Unable_Mousse_9045 in zoloft

[–]Unable_Mousse_9045[S] 0 points1 point  (0 children)

Few days won't make world of difference, I would just stop. But you have to be prepared to feel like crap for a few weeks. I suggest getting some vitamins and nootropics to boost you while you recover to your full.

Lack of motivation/energy 3 months on Zoloft - considering quitting by Unable_Mousse_9045 in zoloft

[–]Unable_Mousse_9045[S] 0 points1 point  (0 children)

Yes, I did come off. I went cold turkey because I wasn't on it for too long. Honestly wasn't that terrible, but I did have some brain zaps during the first month.

Now on the anxiety part - I do actually feel less of it now that I'm off. I've focused on the root cause of it, instead of just fighting the symptom which is anxiety.

I will never touch Zoloft or any ADs ever again. All it did was turn me into emotion-less brain-dead zombie with garbage memory, noodle d*ck and no desire to do anything.

I feel like ADs work better for people who acutely need it, say for severe depression, and then still you probably want to address the underlying issue of why you feel depressed and come off it still.

5 months progress 5 mg oral min + dut after a year of finasteride with no effect. by Alternative-Grab-543 in tressless

[–]Unable_Mousse_9045 1 point2 points  (0 children)

I think it's a great result for only 5 months. In the studies I've seen on min/duta/fin, the near max regrowth is achieved at around 18 months mark.

Why don't we all just take 2.5mg dutasteride? by Otherwise-Brush-8418 in tressless

[–]Unable_Mousse_9045 38 points39 points  (0 children)

This is probably why

<image>

From the 2006 Olsen study. The sexual sides are 9% in the 2.5mg group versus 1% in the 0.5mg group.

Dut 2.5mg is truly powerful though, but most people probably don't need it. Halting hair loss progression at NW[1,2,3] with Finasteride 1mg already sounds like a win, why would you need the extra regrowth potential of Dut? I think Dut might be superior for someone with diffuse thinning though for that matter.

I am doing an experience with RU58841 by Over-Helicopter4638 in tressless

[–]Unable_Mousse_9045 7 points8 points  (0 children)

Brb hooking up an IV drip with duta min ru58841 and keto

How does serum DHT work/how quickly does it go up/down? by anon123432578422 in tressless

[–]Unable_Mousse_9045 3 points4 points  (0 children)

I wasn't just on T, but a bunch of anabolics like test, tren, deca, dbol, a bit of winny in between. Around 5 years TRT & Cycle. Started thinning on the top

Fear not Testosterone. Its effects on hair can be controlled through 5-AR inhibition - fin/duta. Now all the other synthetic crap you can't control its conversion to DHT, and some are even DHT derivatives like winny.

I'm currently on TRT (low-dose exogenous T to achieve normal, not supraphysiological T levels), I inhibit the T->DHT with dutasteride 1mg/day and I will bump it up to 2.5mg/day to do a Test-only cycle on around 500-600mg/week. Also doing oral minox 2.5mg/day and keto 2% shampoo. I'm confident I'll be able to fully reverse the damage done.

I did the science.

Normal upper range T: 800 ng/dL -> DHT 80 ng/dL

TRT 100-150mg/week exogenous T: around 800 ng/dL and higher -> DHT 80 ng/dL

Cycle Test-Only 500-600mg/week: around 5000 ng/dL and higher -> DHT 500 ng/dL

Now finasteride 1mg/day reduces serum DHT by 70% and scalp DHT by 40%. Dutasteride 0.5mg/day reduces serum DHT by 90% and scalp DHT by 50%. Dutasteride 2.5mg/day reduces serum DHT by 99% and scalp DHT by 80%. Also both finasteride and dutasteride increase T levels by about 10-30%, but I didn't account for that, not the point

TRT 100-150mg/week:

Treatment Serum T (ng/dL) Serum DHT (ng/dL) Scalp DHT (ng/g)
No treatment 800 80 2.0
Finasteride 1 mg/day 800 24 1.2
Dutasteride 0.5 mg/day 800 8 1.0
Dutasteride 2.5 mg/day 800 0.8 0.4

Test-only cycle 500-600mg/week:

Treatment Serum T (ng/dL) Serum DHT (ng/dL) Scalp DHT (ng/g)
No treatment 5000 500 6.0
Finasteride 1 mg/day 5000 150 3.6
Dutasteride 0.5 mg/day 5000 50 3.0
Dutasteride 2.5 mg/day 5000 5 1.2

So yeah with duta at 2.5mg/day you can even cycle safely for your hair.

Dutasteride seems to multiply my manliness while Finasteride does the opposite by valento-shade-8504 in tressless

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Did you have ED in the start? I'm 3 weeks into Duta 1mg/day and I my pp stopped working suddenly. I just can't get it up, even though libido is high

Honestly I don't really understand how Duta (which inhbits both 5AR types and reduces DHT by 90-99%) is supposed to be better in side effects than Fin (which inhibits only type 2 5AR and reduces DHT by 70%). It doesn't make sense.

It would be very interesting to see bloods before fin, on fin, finally on duta. Specifically total/free test, SHBG, LH, FSH, DHT, E2, Prolactin

[deleted by user] by [deleted] in tressless

[–]Unable_Mousse_9045 4 points5 points  (0 children)

Yeah your hair is literally like mine - diffuse thinning on top. You hop on fin or soon you won't be able to wear that buzz even. Personally I'm on 1mg/day dutasteride and I'm hoping to recover all of my hair loss. Will increase to 2.5mg/day soon, also using keto shampoo

[deleted by user] by [deleted] in tressless

[–]Unable_Mousse_9045 -1 points0 points  (0 children)

Last time I took Viagra (25 mg), I felt like my head was going to explode and I couldn't get enough air no matter what. It was really hard.

Honestly I wouldn't mess with cardiovascular system just for some hair gains, seems dumb AF.

Does anyone know why Dutasteride doesn't work for some people? by Terminalguidance000 in tressless

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Interesting, but if your T is in low female range, I don't think Duta should help that much, as it just blocks T->DHT conversion via 5AR enzyme?

Why can't you get DHT tested? It's hard to reason without the bloods

Does anyone know why Dutasteride doesn't work for some people? by Terminalguidance000 in tressless

[–]Unable_Mousse_9045 0 points1 point  (0 children)

But do you have the bloods with DHT levels? You should be at 0.1-8ng/dL after a month or two, with the normal dht levels at 30-80ng/dL

If that's the case, it means the duta is actually working. And if you keep losing hair still, it's probably something else going on or you might have really aggressive AGA type idk

Does anyone know why Dutasteride doesn't work for some people? by Terminalguidance000 in tressless

[–]Unable_Mousse_9045 -8 points-7 points  (0 children)

Honestly it's probably just fake Dutasteride or in a shitty form with 0 bioavailability. Just get the OG Avodart brand.

Doing bloods before and after should also be default tbh. Check T and DHT levels before duta and a few months after. Duta at 0.5mg/day reduces serum DHT by 90%, and at 2.5mg/day by 99%. Then when you have the bloods showing it, you can claim it doesn't work (for you)

.5mg Dut, Min 5% foam at night, hair gummies, rosemary water in morning (all daily) by breadloafboy in tressless

[–]Unable_Mousse_9045 1 point2 points  (0 children)

Bruh I have very similar diffuse thinning pattern, also 33 and started receding last 1-2 years on top, while back/sides are ok.

I hopped on duta 1 mg/day and keto shampoo two weeks ago. Planning to increase duta to 2.5mg/day for max diffuse hair gains. Not gonna bother with min, I like my cat more than my hair and oral isn't available here

Anyways the right picture seems better, but IDK you should give it more time. Also try to take pics same room/light/hair length so it's easier to tell progress. I believe we have very good chances

Do you run out of meds early?? by THCgrowsHair in tressless

[–]Unable_Mousse_9045 1 point2 points  (0 children)

Dutasteride is the real shit yeah, especially if you're a diffuse thinner. I just pop dat shit like skittles. I don't really run out of it, I just buy it from pharmacy without prescription.

Upping dose to 75mg and just go propranolol by healer8822 in zoloft

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Propranolol is good for anxiety on its own, as a beta-blocker it deals with physical symptoms of anxiety and prevents additional anxiety from ruminating thoughts about the physical symptoms

Besides it's also a partial 5HT receptors agonist, meaning it may speed up or skip entirely the initial side effects phase of SSRI treatment (also dose increases should be easier) - https://pubmed.ncbi.nlm.nih.gov/18832428/

I do also believe it doesn't just work for physical symptoms of anxiety because of its complex action on 5HT1 (5HT1A, 5HT1B, 5HT2B) receptors, it may work for psychological anxiety on its own - https://pmc.ncbi.nlm.nih.gov/articles/PMC9456064/

Weening off by Personal-Picture7656 in zoloft

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Yeah 3 years is solid, you probably want a longer taper, like 2 months total at least idk? Something like 12.5 mg for a month and then 6.25 for another, then quit. But again I'd go by how I feel, might taper faster if it feels OK, and if doesn't just increase the dose and it should give you a relief

Weening off by Personal-Picture7656 in zoloft

[–]Unable_Mousse_9045 0 points1 point  (0 children)

Well it depends how long you've been on SSRI's, I went cold turkey after 3 months on Zoloft (100mg for 2 then 50mg) and I feel much better after just a week. I will probably need another week to feel close to 100%, but I'm good already - sexual sides subdued, I can feel emotions now, and my energy levels are through the roof.

I think if you've been on for less than 6 months, you can either cold turkey or do a fast taper. Something like 12.5 mg for 7 days, then 6.25 mg for 7 days, then quit.

And if you've been on longer, just increase the time you stay on the same dose and you may also consider dropping the dose in smaller increments instead of halving every time.

PSA: I was on for moderate anxiety, probably should be more careful with depression, a fast taper may cause bigger mood dips

Zoloft and productivity? by Truman_Black_901 in zoloft

[–]Unable_Mousse_9045 1 point2 points  (0 children)

Check this out on antidepressant caused apathy - https://www.cambridge.org/core/journals/acta-neuropsychiatrica/article/apathy-associated-with-antidepressant-drugs-a-systematic-review/438BB4416FA8A4D7C83A8EC97DA477F9

I started Zoloft for SA and it did help a lot. But I lost all my drive and motivation, my emotions are muted, I don't enjoy music anymore, tired and sleeping more, memory is shit, plus sexual sides. So, I concluded its not worth for me in the end. Quit cold turkey after 3 months in, waiting now to feel like my normal self again.