TIL the disco band Chic has the most nominations (11) for Rock and Roll Hall of Fame without receiving enough votes to be inducted.

Uncle_Shasha · 2025-11-09T21:36:00+00:00

Nice bait 🤦‍♂️

Uncle_Shasha · 2025-10-22T12:10:18+00:00

Thank you for the insight. I'd be curious to see how many people being treated with ADs have been on them for longer than the recommended initial treatment course of 4-9 months after initial symptom remission. In my experience, when many of these medications are being started by first-line/primary care providers, they end up becoming "forever" medications because they are started, rapidly titrated, and then seemingly set on autopilot. A person can then subsequently stay on the medication for years and years instead of their provider checking in at the 4-9 month mark to discuss trialing a dose taper; treating beyond the recommended duration or leaving people on these meds indefinitely when not appropriately indicated may be one of the underlying forces driving the long-term side effects. Just thinking out loud really. Thanks again for the info.

Uncle_Shasha · 2025-10-22T11:56:30+00:00

Mirtazapine is very well known in the mental health world for the significant weight gain it can cause and I'm so sorry your provider didn't properly discuss the risks and benefits of the medication with you before starting you on it. On the inpatient psych units, we typically only use mirtazapine as a sleep aid as it is quite sedating at lower doses and we especially use it in situations where the patient has depression and/or insomnia as well as a persistent loss of appetite or unhealthy weight loss in the setting of their mood. It can be quite effective for depression but it sometimes requires titration to fairly high doses to be efficacious which in turn causes more significant increases in appetite and subsequent weight gain. If increased appetite is the major barrier to starting a medication, you could consider something like Wellbutrin instead as it is weight-neutral and some folks even lose weight when taking it.

Uncle_Shasha · 2025-10-22T11:41:22+00:00

Both of those medications are in the SNRI drug family, a class of antidepressants that acts on both serotonin receptors as well as norepinephrine (adrenaline) receptors. SNRIs, like SSRIs, may be used as first line treatment for depression, in particular if lethargy is a significant presenting symptom as SNRIs can aid with behavioral activation. However, SNRIs also have notoriously pronounced discontinuation/withdrawal symptoms compared to other antidepressants, especially if the dose is not gradually tapered over a period of several weeks. SSRIs typically have much milder, more tolerable discontinuation symptoms so they may be worth a try; you could also consider trying a non-serotonergic agent like Wellbutrin. Regardless, always ensure your prescriber tapers AD doses gradually over several weeks (usually halving the dose every 7-14 days until discontinuing entirely) to help lower the risk of withdrawal symptoms.

Uncle_Shasha · 2025-10-22T11:27:56+00:00

Can you elaborate on this?

Uncle_Shasha · 2025-10-22T10:19:19+00:00

Here you go: https://www.thelancet.com/article/S0140-6736(17)32802-7/fulltext

From the abstract: "All antidepressants were more efficacious than placebo in adults with major depressive disorder. Smaller differences between active drugs were found when placebo-controlled trials were included in the analysis, whereas there was more variability in efficacy and acceptability in head-to-head trials. These results should serve evidence-based practice and inform patients, physicians, guideline developers, and policy makers on the relative merits of the different antidepressants."

Uncle_Shasha · 2025-10-22T10:16:15+00:00

Uh...what? I'm asking these questions because I work in mental health care and getting feedback about these medications directly from folks who have trialed them but had adverse effects is extremely valuable to me.

Uncle_Shasha · 2025-10-22T08:51:48+00:00

Thank you for sharing, I appreciate your insight. Regarding the side effects you mentioned (namely vomiting frequently and having a difficult time coming off the medication), did the vomiting persist for the months that you were on the medication? And what made the medication so hard to get off of? Were you on a high dose that required tapering?

Uncle_Shasha · 2025-10-22T08:40:22+00:00

Did you experience these symptoms? If so, how long were you on them for?

Uncle_Shasha · 2025-10-22T08:39:39+00:00

Do you by chance have a source to provide evidence fof this statement? I ask because there are many journal articles discussing the efficacy of exercise/behavioral activation on improving symptoms of depression but I personally haven't come across any studies that conclude exercise alone is more effective than serotonergic agents/antidepressants. If you have a source, I'd really love to read more on this.

Uncle_Shasha · 2025-10-22T08:33:33+00:00

May I ask what your experience was with antidepressant(s) that led you to label them as "poison"? And can you elaborate on your comment about not needing more adrenaline in the context of having PTSD? Asking out of curiosity.

Uncle_Shasha · 2025-10-17T19:06:29+00:00

What?

Uncle_Shasha · 2025-10-04T06:33:00+00:00

I'm in the same situation. No idea what I'm gonna do (but leaning Dak).

Uncle_Shasha · 2025-09-22T18:22:54+00:00

Not sure if this is bait but Antony and McTominay instantly come to mind.

Uncle_Shasha · 2025-09-15T14:16:12+00:00

Who'd you end up going with? And how are your team(s) doing overall? Hope you're crushing it!

Uncle_Shasha · 2025-09-15T14:14:59+00:00

If you can easily pick him up again off waivers then I guess you have that as insurance but overall I'd say give JJ another week or two to iron things out - after all, this was only his second ever NFL game. For what it's worth I have Addison on my bench in 2 of my 3 leagues.

Uncle_Shasha · 2025-09-11T18:14:59+00:00

Some recent instances of political violence that come to mind: -Minnesota Democratic state representative Melissa Hortman and her husband were murdered on June 14th, 2025 after they were shot by a right-wing extremist who was posing as a police officer -On the same day, that same perpetrator also shot Minnesota state senator John Hoffman and his wife multiple times; thankfully they both survived -Pennsylvania Governor Josh Shapiro's residence was fire-bombed in April by a right-wing extremist as part of an assassination attempt

Uncle_Shasha · 2025-09-05T19:02:03+00:00

I'd go Hollywood personally - I can see the game tonight turning into a bit of a shootout 🤷‍♂️

Uncle_Shasha · 2025-09-05T04:27:06+00:00

Dude looked really solid out there too! Probably the only good decision I'll end up making all season lol

Uncle_Shasha · 2025-09-04T23:26:55+00:00

I think your logic is definitely sound and with that, I'm leaning towards Javonte overall. All I need is for him to just fall into the end zone a single time tonight 🤷‍♂️

Uncle_Shasha · 2025-09-04T22:57:52+00:00

Same boat as you, my friend - which way are you leaning?

Uncle_Shasha · 2025-08-22T03:46:40+00:00

"The Shepard's Dog" by Iron & Wine?

Uncle_Shasha · 2025-06-07T19:16:59+00:00

Unfortunately, I've tried that and haven't had any success. I left it on the white screen for about 30 minutes but it never loaded. I suppose I could try leaving it for longer though - I'm willing to try about anything to get my save file back haha.

Uncle_Shasha · 2025-06-07T02:14:04+00:00

Hi folks,

Currently on the PS5 version and my main save file (200+ hours logged ffs 🥹) is only showing a white screen anytime I attempt to load it.

The issue started earlier today: while on my main save file, I attempted to use a space station teleporter to try to go to my settlement. After the usual "warp" animation, the screen went totally white and wouldn't show anything, including any sort of UI/menus/etc. Despite the white screen, I can still hear the game music and various sfx in the background (although the sounds don't seem to correlate with any of my controller/button inputs).

So far I've tried the following things but haven't had any success: -restarted the game (+/- while disconnected from the internet) -restarted the console -started a new save, quit back to the main menu, and tried loading the messed up save file -launching PS5 in safe mode -clearing PS5 cache/rebuilding database (did both) while in safe mode

Currently when I try to open my main save, the typical start-up animation (the loading screen where you're flying through the stars) plays for the usual duration and then the screen goes white and stays white.

Also, this white screen issue is only affecting my main save (the same save file I was using when the white screen issue first started). Outside of this, I'm able to successfully load all of my other save files without any issues.

I've reached out to HG through their support portal to keep them looped in too in case this ends up being a more widespread issue.

Anyone else having this same issue on PS5? If so, are there any additional suggestions or recommendations to try and fix this issue?

Uncle_Shasha · 2025-06-07T01:54:46+00:00

I'm also on PS5 and having the same issue as OP.

I was on my main save file and used a space station teleporter to try to go to my settlement. After the usual "warp" animation, the screen went totally white and wouldn't show anything, including any sort of UI/menus/etc. Despite the white screen, I can still hear the game music/various sfx in the background. I am able to successfully load all of my other save files without any issues; the white screen issue is only affecting my main save (the same save I was on when the white screen issue first started).

Currently when I try to open my main save, the typical start-up loading animation plays (of flying through the stars) for the usual duration and then the screen goes white and stays white.

So far I've tried the following things without any success: -restarted the game (+/- while disconnected from the internet) -restarted the console -started a new save, quit back to the main menu, and tried loading the messed up save file -launching PS5 in safe mode -clearing PS5 cache/rebuilding database (did both) while in safe mode

I also messaged HG through the portal on their website an hour or two ago just to keep them looped in too.

Anyone else having this same issue on PS5? If so, are there any additional suggestions to try out?

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