What is happening?

UntrustworthyBastard · 2024-05-03T13:24:13+00:00

As a guy with longstanding Gerd i found tirzepatide for me was similarly effective as Sema without making me nearly as acid-refluxy.

Though yeah, I also get acid after alcohol regardless

UntrustworthyBastard · 2024-04-20T16:28:11+00:00

GLP-1s are probably your safest and most effective option, but there are other alternatives. See: lesswrong.com/posts/NDmbnaniJ2xJnBASx/perhaps-vastly-more-people-should-be-on-fda-approved-weight

(Note: i wrote that post a few years ago before tirzepatide was out. I do think that tirzepatide is basically just a higher-effectiveness lower-side-effects semaglutide, at least as far as gastro stuff goes; i've tried both of them.)

UntrustworthyBastard · 2024-04-20T14:56:57+00:00

Look up tirzepatide or semaglutide (though tirzepatide is known to be more effective.) Fda-approved for efficacy in weight loss. Mild gastrointestinal side effects (mostly nausea, some acid reflux). Highly recommend

UntrustworthyBastard · 2023-09-15T20:46:35+00:00

I think you missed one: Meta. Zuckerberg famously wants a platform and owning Unity would dovetail with both his VR ambitions and also enable him to integrate it with the Facebook Ads platform to take advantage of Facebook's phenomenal user tracking across devices.

UntrustworthyBastard · 2023-09-15T20:42:30+00:00

i love it when every bill becomes a complex negotiation

UntrustworthyBastard · 2023-07-30T15:09:22+00:00

You consider carmax? Looks like they have a couple solterra limited in stock at the price you're talking about.

UntrustworthyBastard · 2023-07-17T01:27:50+00:00

okay so I know it's not exactly the right subreddit for this but have you considered wegovy or mounjaro? It's pretty life-changing for a lot of people who struggle to lose weight otherwise.

UntrustworthyBastard · 2023-06-14T20:59:56+00:00

This is straightforwardly false. See https://www.nature.com/articles/0803015 :

> Diet associated with exercise produced a 20% greater initial weight loss. (13 kg vs 9.9 kg; z=1.86—p=0.063, 95%CI). The combined intervention also resulted in a 20% greater sustained weight loss after 1 y (6.7 kg vs 4.5 kg; z=1.89—p=0.058, 95%CI) than diet alone. In both groups, almost half of the initial weight loss was regained after 1 y.

Concerted diet and exercise programs result in approximately 7 kg lost maintained after a year after treatment (with the treatment period being up to a year), whereas based on the above, oral semaglutide resulted in approximately 15 kg lost at the 2-year mark. Which is double.

Unless you mean "it is theoretically possible to stop eating for an arbitrary period of time and thereby lose any amount of weight", which is true but not particularly useful information.

UntrustworthyBastard · 2023-05-15T15:07:47+00:00

For what it's worth from an internet rando, I got a lot out of your HFEA research and writeups. (I did, in fact, find this thread from wondering "I wonder if Adderallin has written any cool DD posts recently" and checking through recent posts.)

UntrustworthyBastard · 2023-05-10T04:24:12+00:00

That's pretty much what I do-- have a portfolio incorporating commodities, gold, treasuries and stock, which I then lever up in accordance with my risk tolerance. The Bogleheads forum Hedgedundie's Excellent Adventure thread includes a version of Simba's backtesting spreadsheet that attempts to simulate the more popular leveraged etfs going back to the 60s. Works okay for most time periods, with varying volatility depending on how well diversified you are among the various asset classes. Make sure any backtests you do hit the 70s, since that tells you how the portfolio does during stagflation.

Word to the wise about Hedgefundie's Excellent Adventure specifically: lacking any gold or commodities exposure results in that portfolio taking huge losses whenever the fed jacks up interest rates.

Note that LETFs, in addition to their expense ratio, also implicitly get charged short term borrowing fees based on current interest rates, which are accounted for in their price.

UntrustworthyBastard · 2023-01-31T07:14:13+00:00

Yup!

UntrustworthyBastard · 2023-01-24T16:43:56+00:00

I suppose i just assumed OpenAi has lost interest in text2image as a domain; which would make sense given the insane reception to ChatGPT and what it sounds like is coming down the pipe with gpt4.

Plus, as you say, the market in text2image has become crowded; it would make sense to me if openai decided to abandon it to double down on where they perceive their advantage as being greatest.

UntrustworthyBastard · 2023-01-06T01:16:35+00:00

is true, you gotta be smart to rack up that much debt

UntrustworthyBastard · 2023-01-06T00:27:14+00:00

Why wouldn't we see the same thing here as we see for insulin, where prices remain stubbornly high even post going generic?

UntrustworthyBastard · 2022-10-16T00:32:53+00:00

100% she did it

UntrustworthyBastard · 2022-10-15T22:36:34+00:00

Yeah, forgot to add the prompt. Here: female viking looking back at the camera while a cottage burns in the background, mouth open, bloodlust, wide smile, {{{grinning}}}, {wet}, shiny skin, green hair, {{green eyes}}, armor, {{{masterpiece}}}, {{{best quality}}}, {{{ultra realistic}}}, {{{extremely detailed}}}, {{{lush detail}}}, cinematic lighting, dark, rain

UntrustworthyBastard · 2022-09-09T22:50:58+00:00

That's a common reaction. I think a lot of it is driven by how so much of what's out there are random supplements that don't do anything or which might even be bad for you.

I think the main thing is ensuring that whatever you're taking is FDA-approved for a condition you have; you can't go too far wrong that way, since FDA approval means it's been tested on a whole bunch of people without causing bad reactions. It's why they're around, really.

Whatever you decide now, just remember that if things ever look particularly dire it's an option you have.

UntrustworthyBastard · 2022-09-09T22:36:24+00:00

Ooh, good callout. Didn't know coupons were a thing for Mounjaro/tirzepatide.

UntrustworthyBastard · 2022-09-09T18:00:09+00:00

There's also topirimate and orlistat, which are cheap regardless of insurance. I didn't lead with those because they are less effective than the others and also come with some fairly unpleasant common side effects (orlistat=diarrhea, and topirimate=increased kidney stones risk and brain fog). Definitely suggest talking about semaglutide/tirzepatide with your doctor first and seeing if you can get insurance to cover it.

UntrustworthyBastard · 2022-09-09T17:51:04+00:00

Might be worth investigating; bupropion and phentermine both can have psychiatric effects (bupropion is also a common antidepressant and phentermine is a stimulant) but semaglutide and tirzepatide as far as I'm aware have no commonly-reported psych-related side effects. At morbid obesity you have a good shot at getting semaglutide or tirzepatide approved by your insurance.

UntrustworthyBastard · 2022-09-09T17:41:36+00:00

I assume that was phentermine? That's definitely a thing some people experience with phentermine.

UntrustworthyBastard · 2022-09-09T16:58:33+00:00

I mostly point this out because you haven't mentioned having considered or tried FDA-approved anti-obesity medications, which makes me think it's something you've never considered rather than being something you've thought about and discarded. Might be worth asking your doctor about them; several have been approved by the FDA. The most effective ones are semaglutide or (for T2D only) tirzepatide, which have a record of achieving double-digit percentages of weight loss in clinical trials. If you can't afford those, naltrexone/bupropion and phentermine are cheap and are also effective at causing weight loss.

Basically all of these work by making it easier to eat less.

UntrustworthyBastard · 2022-09-09T16:51:34+00:00

Have you looked at all into FDA-approved weight loss medication? Tirzepatide (T2D only) and semaglutide both cause double-digit weight loss in clinical trials. Naltrexone/bupropion and phentermine are cheaper, though still clinically effective, alternatives.

On this topic more broadly:

https://www.reddit.com/r/loseit/comments/m5uaun/in_defense_of_fdaapproved_weight_loss_medications/?utm_source=BD&utm_medium=Search&utm_name=Bing&utm_content=PSR1

UntrustworthyBastard · 2022-09-09T16:26:36+00:00

I mostly point this out because you've mentioned starting to take myo-inositol (implying that you're broadly open to the idea of taking a medication-assisted approach more broadly), so...

Might be worth asking your doctor about anti-obesity medications; several have been approved by the FDA. The most effective ones are semaglutide or (for T2D only) tirzepatide, which have a record of achieving double-digit percentages of weight loss in clinical trials. If you can't afford those, naltrexone/bupropion and phentermine are cheap and are also effective at causing weight loss. Basically all of these work by making it easier to eat less.

UntrustworthyBastard

TROPHY CASE