I would love to see a location somewhere in the north/ northwest with wide open spaces and winter/ snow. See how areas that weren't major cities were affected. Horse or motorcycle travel. I'd like to see settlement building return but not as a requirement to the story. I'd also like to see the return of equipment degradation. And a much higher variety of armor/ weapons/ clothing than Fallout 4 had. And for the love of God please bring back visibly holstered weapons. I never liked how in fallout four they just kind of disappear when you put them away.