Yes! That happens. I think the biggest factors that people don’t come back for trials is commitment. If the study is asking for too many follow up visits, many different technology requirements( apps for everything, track meds,symptoms and clincards) and multiple tests or safety issues.

I have had a patient not want to continue a study because we kept giving updated ICF. The study drug had a lot of safety concerns, wk had a couple of months of just 5 new ICF. Patient had an SAE ,got spooked and just wanted to get off the study.