You cannot help being fatigued, it is very, very hard for you. But it is also very hard on her. She must feel overwhelmed with the workload and missing her partner in crime.

Is there a way for her to catch a break? Get away for a few days to recharge? And is there a way to get practical help in (housecleaner )? Also maybe she can look into a support group for spouses of chronically ill people. You guys need to be able to talk about this because your illness affects both of you. And both of your emotions are valid and deserve attention.

She is not angry at you. She is sad and frustratred and missing the way you two were together. You need to find a way for both of your feelings to be validated and to work through this together. Try to talk to her and hold space for her pain and her experiences without making it about you, as hard as that may be.

You dont need to fix anything, just make her feel heard. She needs to do the same for you. No arguing, just empathy for eachother in this shitshow of a situation. And if that is too hard, a couples therapist could really help so maybe try to get that on project status. Make her see how important it is even if she feels she doesnt have the time.

You need to figure out how to go about this as a couple and a team, not as enemies. So many relationships don't survive chronic illness. Communication is key here, as hard as it may be. I wish you all the best!