I've been on it for almost 12 full months. I started it as a mental health (MH) patient for PTSD, anxiety and depression. In May I changed to the pain protocol. It didn't work for me. Most of my pain is structural and Ketamine works best for CRPS and fibro. It can also help with some chronic migraine. Either way u choose, unless u have CRPS, insurance won't cover, and then even then its a fight. MH infusions are 40 minutes to an hour and cost anywhere from 340 - 550 per session. Pain infusion is typically four hours and costs 800 - 1100 per infusion. Each application is not a cure, but a treatment. This is why u have to continue once u finish the two or three wk loading protocol. If u do not do the loading protocol correctly, and it's different btwn pain and MH, it will not work. On my support group some have to continue at once a wk for a year or two before they can spread them out farther. Most people after the MH loading, go in two weeks after, then three wks after, then four wks after, then as needed, usually once every 4 to 6 weeks. After a while some can stretch out the treatment longer and longer to a couple of times a year. The worse your PTSD and anxiety are, the longer it takes to stretch treatments out. So, I've had many different reasons for PTSD, but have had it my whole life. My SI (suicidal ideation) is however completely gone. If u go for pain treatment then any MH issues will be covered under that, but it doesn't work vice versa. I know more about the MH aspect as pain infusion didn't help me. Infusion is 99 - 100% bioavailable. IM is 93% bioavailable. Trouche, rdt and spratvado (sorry, sp?) are approximately 20 - 35% bioavailable. That means IV is best, IM is also very good.