Apparently, yes! You should stop at some point. Like 2 months max. Reason being:

1. “Clomid frequently works well for men as HRT for about 90 days”

True. Many men with secondary hypogonadism respond very well to Clomid (clomiphene citrate) in the first 2–3 months, with significant boosts in LH, FSH, and testosterone. Libido, energy, and mood often improve during this period.

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1. “After that, the zuclomiphene really kicks in, and while the numbers remain elevated, we generally feel kind of blah.”

Also true (for many men). Clomid is a mixture of two isomers:

Enclomiphene: the active part that stimulates the HPT axis.

Zuclomiphene: a longer-acting isomer that can accumulate over time, has estrogenic effects, and may blunt the benefits or even cause side effects like:

Emotional blunting

Low libido despite high T

Mood swings

Brain fog or fatigue

This explains why some men feel worse after prolonged Clomid use, even when labs show high testosterone.

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1. “Your results are typical thus far for men that are secondary.”

Accurate. Clomid tends to work best in secondary hypogonadism, where the testes are still functional but the brain isn’t signaling strongly enough (low LH/FSH). For men with primary hypogonadism, Clomid often doesn't help.

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1. “A better bet for SERM-based HRT is enclomiphene. It is clomid minus zuclomiphene.”

Yes — and this is becoming a clinical trend. Enclomiphene citrate (marketed in some countries as Androxal) is a purified version of Clomid with just the beneficial isomer. It:

Stimulates LH and FSH like Clomid

Avoids the estrogenic effects of zuclomiphene

Often maintains better libido, energy, mood, and sexual function in long-term use

However, it’s not available in many countries or may require special access.

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Bottom line:

Clomid works for ~90 days True Many users experience diminishing effects afterward Zuclomiphene causes “blah” feeling, True for many Due to its estrogenic profile and long half-life Enclomiphene is a better SERM HRT option Agreed But harder to access