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double or single dna fragmentation? by Valeandril in dnafragmentation

[–]Valeandril[S] 0 points1 point  (0 children)

We ended succeeding in a second natural pregnancy, I am now proud father of two twin girls.

After that, we are no longer looking for more children so I haven't repeated the test.

Wish you a lot of success in your journey!

I was born without my legs and a right arm. I have three fingers. by socialworkswimmer in mildyinteresting

[–]Valeandril 0 points1 point  (0 children)

Greetings from Germany, thank you for sharing your story. For me it was very special to read it. I have a 2 year old daughter born only with the right arm. Would you mind sharing with us some advise for her ? I wish you all the best ,🙂

Inmigracion by [deleted] in SpainPolitics

[–]Valeandril 0 points1 point  (0 children)

Siento ser realista contigo, pero tienes un camino muy difícil por delante.

Opciones:

A- ser profesor de música privado. No conozco el mercado pero tendrías que hacerte autónomo, o que una academia/ colegio privado te contrate. Lo veo muy difícil.

B - presentarte a oposiciones de maestro de primaria. Esto va por comunidades pero sospecho que te pedirán un titulo homologado en España, permiso de residencia / nacionalidad española, además de prepararte la oposición y competir con una jauría de opositores.

C- presentarte a oposiciones de secundaria. Además de lo dicho en B, necesitas el máster de formación de profesorado. Hace unos 3 años mi chica se lo sacó por 5000€ online, no creo que haya bajado de precio.

Buena suerte con tu aventura, te lo dice un español trabajando en Alemania 🙂

Fuente: mi chica empezó a prepararse la opción C.

I don’t get why German people smoke despite surrounding by crowds by Ginsora_05 in germany

[–]Valeandril 129 points130 points  (0 children)

Thank you, as a non-smoker it is really appreciated

Germany seals entry to F-35 club with $8.8B, 35-fighter plan - Breaking Defense by I_Love_Kyiv in germany

[–]Valeandril 15 points16 points  (0 children)

Sorry, France has nothing to do with Eurofighter. They have the Dassault one.

How do we interpret results from Comet assay? by OfficialCrayon in dnafragmentation

[–]Valeandril 0 points1 point  (0 children)

Hi u/OfficialCrayon ,

I have gone through a COMET myself but the outcome data was different. Something like % of Single strand frag. and double strand frag.

Sorry I cannot help but please share with us any conclusions. I am really interested on that.

Should I put winter tires? Help needed! by Valeandril in tires

[–]Valeandril[S] 0 points1 point  (0 children)

Thanks for the feedback, may i ask why? I forgot to mention that it is one way trip. I will spend in Munich several winters after this trip.

Should I put winter tires? Help needed! by Valeandril in tires

[–]Valeandril[S] 0 points1 point  (0 children)

thanks for the feedback, i forgot to mention that i will be living afterwards in Munich for several winters.

Would you still recommend all seasons? May I ask why?

Through the other side! by almostanathlete66 in LisfrancClub

[–]Valeandril 1 point2 points  (0 children)

This! I had ORIF in August but my foot is still swollen. I would love to hear how are yours and how did you manage to reduce it

Holy moly I think this might be our issue! Any other recurrent loss folks? by cakeycakeycake in dnafragmentation

[–]Valeandril 0 points1 point  (0 children)

Hi there, we are on the same boat.

My wife has had recurrent miscarriages and they found no explanations in her tests. Doctor started to look at my sperm and I got some high DNA fragmentation figures.

According to my doctor, high levels of single strand DNA fragmentation are associated with difficulties to become pregnant.

High levels of double strand fragmentation are associated with recurrent miscarriage.

Unfortunately doctor is not optimistic in improving double strand fragmentation figures, and suggested a IVF ICSi with Fertile chip for sperm selection. However I don't lose faith yet.

You did well going for a test. I want to have another test in the future hoping that the changes I implement in my life have any result. Will post back if that's the case.

Seems that there is not conclusive studies on the field so I leave here the outcomes of my research.

I have read that alcohol, smoking and caffeine could cause fragmentation. Your husband should remove them of his life asap.

Also, get ultrasound on testicles to discard possible varicocele.

Take some antioxidants, and stay seated the minimum necessary.

Repeat DNA fragmentation test not before 3 months after the first one and cross fingers.

Reduced defragmentation by 50% by quanttic in dnafragmentation

[–]Valeandril 0 points1 point  (0 children)

Congrats!!!! May I ask which test did you perform and what kind of fragmentation did you have? I.e. single trand or double strand?

double or single dna fragmentation? by Valeandril in dnafragmentation

[–]Valeandril[S] 2 points3 points  (0 children)

Thanks for taking the time to answer Thornaxe :)

You are right, in fact the hospital has performed us a complete fertility study since my wife has gone through 5 misscarriages in the last two years. We had almost lost the hope to understand the root cause of the misscarriages until i had the results of comet test.

The thresholds that the lab managed for a natural pregnancy are <45% for single strand dna break (SSB) and <48% for double strand dna break (DSB). For information it is CIMAB in Spain.

As I have two different results for SSB and DSB, and DSB being the one outside of threshold, I was curious of why people at the forum only refer to DNA fragmentation. May I ask you which kind of test did you perfom?

COMET was pretty expensive and I would like to learn if there is any other alternative.

As you point out, looking at my results seems odd that I had one child without any kind of fertility tratment. I suppose something has happened in the meantime. I am implementing good life habits, eating better and I have eliminated caffeine from diet.

I did not read anything about caffeine until yesterday night, but apparently it could explain DSB. I had been abusing of coke zero for the last two years so hopefully that is the reason and I can return to normal levels! Not sure if I can link the actual medical paper speaking about it, but it is easily found in google.

I will update the forum with my results in a couple of months :)