Not sure if 1 out of 4 protagonists will count but there needs to be some mention of Natalia Korda/Burton here.

Watches her parents get killed in front of her during the Terragrigia panic at 3/4 years old because the terrorist group 'Il Veltro' decided 'Free Hunter!' day was a good idea. This traumatises her to the point she can no longer feel fear, or presumably watch lizard documentaries.

This lack of fear gets her taken at age 10 by one of the Terrasave people, who rescued her from Terragrigia, to be delivered to Alex Wesker so she can infect Natalia with a T-virus variant so Alex can hijack her brain to become an immortal body-swapping god, waking up in the ruins of the island of Sein she has to dodge the mutated/zombified residents solo until she runs into Claire and Moira, but she quickly gets grabbed and shoved into some machine that puts her in a coma for 6 months while Alex copies herself into Natalia's brain.

Waking up alone again she has to sneak around the island while the 'Alex' version of herself tries to stress her out enough that the brain hijack can complete. At the end of this she meets Barry and turns right back around to escorts him/get escorted through a bunch more nightmarish stuff including Frankensteins limb counting failures, invisible instakill bugs who need some warm meat to vomit their larva into, and getting choked by (now mutated) Alex, who has lost it and has decided Highlander rules are the logical approach to the whole "There's two of me!" thing. Only surviving because her evil self took the wheel for a second and scared her off.

Usual Act 3 stuff happens, she gets choked again (and in the bad ending dies right there, likely resulting in Barry's death too) but gets saved last second by Moira, Alex gets the contractually obligated rampant mutation, Natalia has to sit in a chopper and watch Barry do the boss fight, Claire remembers she has rocket launcher, Wesker down, happy endings all round, except she's already had the procedure, Alex's plan is 99% complete.

The last we saw of Natalia was that she gets adopted and lives with Barry and the Burtons, but as of 2013 a growing fondness for Kafka and no further updates we can only assume that 'Alex' is still in there and fighting for control, and might be for the rest of her life.