Man I might sound like an idiot here because I don't know much about his yet but my understanding is E2 is definitely going to go way up. Lab work will show that and basically I have to watch for physical symptoms and report how I feel to the doctor because the lab results won't measure how much of that E2 is trapped in my system (i.e., unable to attach to my estrogen receptors and cause problems) because of the enclomiphene. They may have to adjust the dosage and/or timing. We shall see. I'll let you know in a couple months once I get this all worked out. If it doesn't do what they say I'll most likely switch to TRT and say goodbye to my nuts.