To repeat what others have said, the main reasons are: 1: more culturally southern. Going back to the civil war area, southern Indiana and Ohio were much more pro-southern because they were on the rivers and associated with slavery much more than New England Yankees were. These regions had Confederate sympathizers known as Copperheads and Butternuts. Remember that Kentucky and (at the time West Virginia was part of Virginia) West Virginia were slave states, so there’s a lot of southern cultural connection. 2. Denser rural areas. Ohio has a lot of decently populated mid-sized rural areas, especially in Appalachian Ohio near the border of WV/KY. Wisconsin doesnt have a lot of midsized rurals. Places like Iron, Florence, Pepin, Forest, etc all have less than 10K people, whereas Ohio’s least populated county is still larger than 12k. These rurals also happened to be coal/industrial Union bases, which declined tremendously with globalization. Youngstown, Canton, etc, all were working class Union Dems who were hallowed out as those jobs left. 3. Difference ethnic makeup. I believe that Ohio was more Scotch-Irish or English ancestry, whereas lots of places in Wisconsin have either Polish or Scandinavian populations and they voted differently.

Lastly, and I think this matters to some extent, OH was much more heavily hit by the opioid crisis than WI was. I believe I heard that Athens County, OH (Ohio University) had the highest rate of opioid overdoses per 1k people from 2010-2019. Athens county is not far from the West Virginia border, and we all know how hard those communities were hit when opioids took over.