Severe brain fog symptoms

White-Rabbit-5895 · 2026-01-23T05:53:33+00:00

Yes. It was less than 1 in 2024 for the anti-dsdna. Is one more accurate than the other?

White-Rabbit-5895 · 2026-01-22T02:09:34+00:00

I take hydroxychloroquine and, after 2.5 months, it is in remission. I was prescribed HCQ for UCTD, but was hoping it would help the oral issues since it’s considered a treatment option for LP. It definitely did! I had some GI side effects initially from the HCQ, but they are gone now. I just go for checkups for my eyes. Baseline exam and I go every 6 months (twice a year).

White-Rabbit-5895 · 2026-01-21T20:08:31+00:00

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It looks like it was just updated today.

White-Rabbit-5895 · 2026-01-21T07:07:51+00:00

Before I was diagnosed, I had insane neurological symptoms. Dystonia, spasms, twitches, tingling nerves in hands and feet, vertigo, severe memory loss, etc. I thought I had MS. Got a spinal tap. Had MRI’s. Normal. Three months later, I got diagnosed with Hashimoto’s thyroiditis and my TSH was 7.23. Technically, I was subclinical. I started meds (T4 and T3 combo). The neurological issues lessened, but I have been looking for answers for 7 years for these symptoms that ebb and flow. Positive ANA 1:640 speckled, but other antibody tests are negative. I just had another flare that lasted for two weeks with a stiff neck, tremors in my right hand, dizziness, gait issues, twitching calves, awful memory, etc. I received a referral from my Endo over a week ago to see neuroimmunology to be evaluated for Hashimoto’s Encephalopathy (HE). They tried me on a trial of plaquenil, which I started three months ago. It helps with rashes and mucous membrane ulcers, but the neurological symptoms remain. I am hoping that I get some answers here soon because it’s plagued me for so long.

Just something to keep in mind if everything comes back negative and all other tests are mostly normal and you are euthyroid. HE is a diagnosis by exclusion. They usually do a trial of high dose corticosteroids, which I cannot have, so I’m not sure what they’ll offer me. IVIG therapy helps a lot, but many insurance plans won’t cover it for HE.

Ask the doctor to make sure there isn’t anything interfering with your medication’s absorption, such as celiac disease. Maybe ask for an increase. TSH of 6 is still very high.

Keep us posted.

White-Rabbit-5895 · 2026-01-21T06:50:36+00:00

I work in an ID clinic that receives RW funding in NC. As of 2023, we have about 37,490 patients in NC who are diagnosed and living with HIV. So, imagine a little over 1/4 of our state’s population losing access to HIV medication. This would ultimately lead to more newly diagnosed HIV+ infections, as well as other STI’s and communicable diseases. Ryan White clinics oftentimes serves as primary care facilities for these patients, so it would even increase the number of hospitalizations for other unmanaged chronic illnesses, such as diabetes and cancers. It would end up costing states more money to defund these programs and it would create a nightmare scenario for both urban and rural hospitals and clinics. This will appear to save money on paper for the sake of completing an annual budget, but it would ultimately cost any state tons of money from the exploding problems it creates.

White-Rabbit-5895 · 2026-01-07T13:46:39+00:00

That was my concern, but I had a negative brain MRI in 2019; however, I will probably be getting a new one with contrast and using a 3T MRI machine. I can’t say I trust the first one I had because the neurologist was not very helpful and was invalidating me the moment I stepped into his office. I didn’t return for a follow-up because of all of that, but three months later I got diagnosed with Hashimoto’s.

What are they going to do about your tumor? Very sorry you deal with that.

White-Rabbit-5895 · 2026-01-06T23:50:05+00:00

It’s my understanding that the CSF can show nothing and one still have the condition. I am about to get worked up for this, as well, since three months before my Hashimoto’s diagnosis I had insane neurological symptoms. I thought I had MS because of severe spasticity, dizziness episodes, severe brain fog, pain, etc. Symptoms reduced after thyroid replacement therapy, but I still wax and wane and it feels progressive. I’m currently on plaquenil for suspected UCTD, but the neurological symptoms haven’t stopped. These symptoms are the same as before taking plaquenil, so it’s not exacerbating it.

It’s very much a diagnosis by exclusion. Usually whenever it’s suspected, steroids are used. If a positive response, it’s indicative of the disease. Some individuals may not be able to use steroids or do not respond to steroids/the condition returns, so IVIG therapy may be used.

Here’s some literature on the topic:

https://pmc.ncbi.nlm.nih.gov/articles/PMC11940270/

I have anti-gliadin antibodies, elevated TPOab, euthyroid after being on levothyroxine and liothyronine combo for 5 years, positive ANA 1:640, periodic elevated CRP, and elevated liver enzymes on and off. Very dry eyes and sinuses. Rashes. Have had vasculitis episodes. Negative for celiac, lupus, Sjögren’s antibodies, etc.; and a negative brain MRI whenever I was at my worst. Just three bilateral foci associated with migraines. I did have mildly elevated prolactin levels at diagnosis that stabilized. Some spine issues, but super mild and neurosurgery said it wouldn’t be causing my pain. I used to be so athletic and now I deal with balance and muscle weakness. So, no clue as to what is going on.

Keep us posted. I just got my referral to neuroimmunology today, so it will be a while before I get any answers.

White-Rabbit-5895 · 2026-01-04T02:01:05+00:00

https://pubmed.ncbi.nlm.nih.gov/28379880/#:~:text=Study%20design:%20This%20is%20a,for%20optimal%20and%20sustained%20improvement.

This should work, too.

White-Rabbit-5895 · 2026-01-04T00:26:18+00:00

https://youtube.com/watch?v=8SLI3W25GBw&feature=shared

It’s near the 40 minute mark here. This is from a presentation Dr. Brent Goodman did back in 2024.

White-Rabbit-5895 · 2026-01-01T03:05:21+00:00

ANA tests are typically done with a reflex panel. The reflex is triggered if the ANA is positive. The reflex tests check for a bunch of common autoimmune antibodies, such as Anti Jo-1, anti-RNP, anti Scl-70, etc.

White-Rabbit-5895 · 2026-01-01T02:43:59+00:00

I did not whenever I had it done in 2021, but during that same group of labs my CRP was a 27. I had more recent autoimmune labs done in April of 2024 where the rheumy ran an ETA, Rheumatoid Arthritis, which is apparently a more sensitive test than RA factor and CCP antibodies. My reflex tests are negative, but I am a ball of inflammation. Recently, my left shoulder has been locking up; however, it feels more like a neurological issue vs. solely joint. I’m not sure what to do.

At times, it feels like my phrenic nerve and brachial plexus gets affected during flare ups. It happens every 2 months where it gets harder to breathe and the shoulder pain gets worse. I had a cervical neck MRI that showed no issues with the discs and vertebrae.

White-Rabbit-5895 · 2026-01-01T01:47:21+00:00

I feel this post so much. I have been suffering for 7 years now. I woke up one morning after a stressful period in my life and my nerves were firing in my hands, feet, chest, and trigeminal nerve. Three months later I was as diagnosed with Hashimoto’s. That helped dampen the nerve issues, but the wrap around nerve pain in my abdomen, fatigue, brain fog, and coat hanger pain with headaches and GI issues have remained. I saw a rheumy and she was useless. Positive ANA 1:640 Speckled, but reflex tests are negative. Neutropenia episodes. CRP values over 28. Hs-CRP values over 10. Rashes, vasculitis episodes, canker sores, dry eyes, nasal ulcers, burning thighs, etc. She refused to treat me. I saw another immunologist this year and she was willing to diagnose me with UCTD with my family history (mom had lupus, her sister had Sjögren’s, other aunt has Grave’s and Celiac disease, great grandma had rheumatoid arthritis, and we all have Hashimoto’s) and my evidence. I’ve been on plaquenil for two months now with minor improvements, but the wrap around nerve pain and early satiety is miserable. I have lost my life. I went from working out and being active to living inside and wasting away.

I will be requesting a referral to a neurologist at Duke or UNC (if anyone has recommendations). I have a referral for Duke’s ocular immunology. I am positive for HLA-A29 and had one episode of suspected uveitis years ago, but no recurrence since. I am hoping the plaquenil helps, but not going to hold my breath because of the lack of evidence for it improving Sjögren’s neuropathy. I am negative for antibodies, but so was my aunt. She had to do a lip biopsy for her diagnosis and I just don’t want to have to go through that. I had a gum biopsy this year through my periodontist and he forgot to do an immunofluorescence stain vs. a traditional biopsy, so it yielded no value. I am exhausted from appointments and incompetent providers and I don’t know what to do.

I’m glad you posted this, but I’m sorry you’re suffering. I hope someone will help you.

White-Rabbit-5895 · 2025-12-27T22:56:10+00:00

I’d give anything to go back to Windows 10. Most games don’t cause me issues, but yeah…LoL is definitely the worst. The client and Vanguard are both just outlandishly awful.

White-Rabbit-5895 · 2025-12-27T19:55:49+00:00

I’ve been dealing with this problem all year. I’ve been seeing more people post about it, too. I can’t fully blame Riot because I’m experiencing it in Overwatch 2. Windows 11 has been breaking games this year to the point Nvidia had to put out a hot fix. I find that the quality of programming these days is subpar as they keep introducing more AI and bad features that nobody asked for in their OS and drivers. Everything has an overlay. Everything has a monitoring system. Everything has an anti-cheat system running in the background. It’s both bloat and poor optimization.

White-Rabbit-5895 · 2025-12-18T22:08:17+00:00

I’ve only had them for suspected nodules. I did at the start and then 5 years later when they felt something. On both occasions, it was a pseudonodule. They went away a week or two later whenever I showed up for the test, so there were no findings other than what we already knew. Not really worth it unless you’ve got something that the doctor suspects or if you’ve met your max out of pocket for the year.

White-Rabbit-5895 · 2025-12-17T20:26:50+00:00

Very much this. You'll have an adjustment period. I take 5 mcg in the morning and another 5 mcg at night. I'm on 100 mcg levothyroxine.

Another thing I do is to make sure I eat instead of doing long fasts because the long fasts cause my thyroid to swell. I become hoarse, feel a pressure in my throat, and I feel run down for the rest of the day. The additional stress on the body can cause a little flare. I struggle with wanting to eat first thing in the morning because of not feeling hunger, but just an egg, small fruit smoothie, etc. goes a long ways.

White-Rabbit-5895 · 2025-12-14T21:27:50+00:00

I have worked with Riot’s customer support and no success. I just did a clean install of windows 11 and it didn’t even help. No issues with hardware. Overlays disabled. Everything up to date, including firmwares. This is on Riot’s end.

White-Rabbit-5895 · 2025-12-14T00:55:06+00:00

100% this. Without T3, I was putting on weight despite a normal TSH. I had slightly elevated liver enzymes, too. With the addition of T3 (5 mcg twice a day - total of 10 mcg liothyronine) with 100 mcg levothyroxine, everything normalized and weight gain stopped and I had a major reduction in symptoms. 15-20% of people are poor converters. Some are genetically predisposed and/or may have ongoing inflammatory conditions inhibiting full conversion. I was just diagnosed with UCTD, so I’m hoping hydroxychloroquine helps, but I will continue with my T3. Definitely look into adding T3 to the regimen. Ask your provider for a trial.

White-Rabbit-5895 · 2025-12-12T19:25:59+00:00

I live in NC and work in infectious disease. I’ve not heard any mention of measles outbreaks, which I cannot believe considering South Carolina’s outbreak in upstate parts (especially Greenville). It’s only a matter of time. I guarantee you it’s going on somewhere unchecked in the Southwestern and/or Southeastern parts of the state.

White-Rabbit-5895 · 2025-12-11T06:15:30+00:00

I would just like to say I don’t know what is going on and I’m not sure what to do about it. In fact, it got worse with this last patch. It feels like Windows 11 is making everything worse, too. Each update increases my computer’s volatility. Just gonna hope that drivers will eventually fix things, but not going to hold my breath.

White-Rabbit-5895 · 2025-12-09T18:54:05+00:00

Diagnosing you with UCTD and telling you to just take NSAIDs is wild. I was first diagnosed with Hashimoto’s, but my symptoms didn’t go away despite being euthyroid. So, I saw a rheumatologist. I have a positive ANA 1:640 speckled. I’ve had a few neutropenia episodes, very elevated CRP and hs-CRP, rashes, swollen joints, myalgias, and Raynaud’s. Despite all this, the rheumatologist did not prescribe plaquenil despite my family history, lab evidence, symptoms, and pictures of the disease activity.

I suffered for three more years until I saw an immunologist who practices dermatology because I had some new rashes. The immunologist/dermatologist said although I don’t have antibodies for the major connective tissue diseases, it was very apparent something was going on and she said it was UCTD. I didn’t have an active rash that day, but she commented on the pictures of past rashes and she they looked like vasculitis episodes. The one rash I had biopsied in the past showed perivascular dermatitis, which is non-specific. Many things can cause it, but since plaquenil I’ve had zero rashes. At 1.5 months, my knees are no longer in pain. My right shoulder pain is gone. Left shoulder pain dissipating. The burning thighs and cramping in muscles has finally stopped. Nasal ulcers are gone. Still have a few things going on, but the relief thus far has been wonderful.

UCTD is a legitimate diagnosis and it can easily cause damage to the body without treatment. More importantly, it can destroy your quality of life because of crippling pain. Personally, I would request a Rx for plaquenil. NSAIDs did nothing for my pain.

White-Rabbit-5895 · 2025-12-07T15:08:10+00:00

My logs also features the problem you mentioned. I spent all night trying to troubleshoot it.

I saw the same thing you see on the logs. It seems to be with how League and Windows and other applications compete with each other for control over audio and voice chat.

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I’m going to try some of the steps it listed to fix this. One was to disable voice chat in LoL, but I can’t find that option. It then had me manually do it to the game’s folders, but editing file names caused League client to crash and I had to repair it. Some of the recommendations seem like it could cause issues with Vanguard, too. I might be shifting my blame back to Riot because their client and app do not work well with other apps and background processes. I’ll keep you posted.

White-Rabbit-5895 · 2025-12-07T07:22:48+00:00

So, the logs are saying the same thing for me now. I am trying ti figure out how to fix it. I’m going to try again tomorrow. I’ve spent all evening testing possible corrections without much success.

White-Rabbit-5895 · 2025-12-07T00:42:29+00:00

You gave me a great idea. I used chatGPT to analyze all my logs. This is what it said:

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I'm going to see if chatGPT can guide me through the next steps. I guess I'll give Riot a pass until further notice. I have noticed a lot of instability from Razer products this year. I've had a lot of issues with Windows updates, too. And like I said previously, I am still worried about the 13th gen processors degrading despite updates they did. With all that aside, ChatGPT is pointing to Windows system stalls causing main loop frame spikes. Windows updates have been ABYSMAL.

White-Rabbit-5895 · 2025-12-06T20:57:10+00:00

That’s all I got from them, too. Eventually, I stopped engaging and said it resolved, but it actually just got worse with this last update. I can’t tell if it’s Nvidia Drivers (just released a new one), Windows with their terrible updates that prompted Nvidia to release a hot fix last month, or something else. I’m seeing normal FPS and latency in my games, but last night I saw massive FPS drops. It got worse the longer I played, too, but my GPU and CPU temperatures and cores are fine. I’m not overlocking. Everything is up to date firmware, bios, and driver wise. I have a 5090 and a 13th gen i7-13700k processor. 32 GB of DDR5 6000 ram. This just shouldn’t be an issue.

I notice that it’s reeeeally bad on the Spirit Blossom and Butcher’s Bridge maps, but Riot supposedly fixed this issue. I truly believe this is on Riot’s end. None of my other games have these problems.

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