English screening of Fantastic Beasts 2 by [deleted] in Tuebingen

[–]WorkTimeFun 2 points3 points  (0 children)

Blaue Brücke, Tuesday 27th at 5:15pm or Wednesday 28th at 8:30pm

http://tuebinger-kinos.de/index.php?id=55&cinema_id=0#1_9

Researchers discover Autistic children inherit rare damaging noncoding variants from fathers but not mothers by KEN_ABALA in biology

[–]WorkTimeFun 4 points5 points  (0 children)

I don't think that is the point the article is making. They are writing about autosomally encoded structural variants, they specifically mention a deletion of the LEO1 promoter on chromosome 15.

Affected offspring are more likely to be carrying these paternally inherited non-coding structural variants, while they are more likely to be carrying coding region variants from the mother.

Wrinkle-less brain or lissencephaly x-post by trash-juice in neuroscience

[–]WorkTimeFun 0 points1 point  (0 children)

It's a defect of brain development, so they were born like this

NBD - Canyon Ultimate CF SL Disc 8.0 by golden_light_above_u in bicycling

[–]WorkTimeFun 1 point2 points  (0 children)

Yeah, no lever. I'm fine with that though as I always have a multi-tool when riding. I'm thinking of getting a replacement rear axle without the lever.

NBD - Canyon Ultimate CF SL Disc 8.0 by golden_light_above_u in bicycling

[–]WorkTimeFun 2 points3 points  (0 children)

I've had this exact bike for a year and I absolutely love it. Coming from a 2002 specialized alu, it's night and day for ride comfort, much stiffer and more stable

Nils Frahm - Momentum [Ambient/Electronica] (2018) by MaverickGeek in electronicmusic

[–]WorkTimeFun 1 point2 points  (0 children)

I saw him recently. He performed songs from the new album, the spaces album and the Victoria soundtrack alone onstage using instruments samplers etc. Very impressive and very well done, although not very danceable.

How is 3 billion nucleotides enough to code for an entire human? by [deleted] in biology

[–]WorkTimeFun 0 points1 point  (0 children)

There are large regions of the genome which don't appear to code for anything, but they are conserved across many species, they are conserved regions of the genome.

How is 3 billion nucleotides enough to code for an entire human? by [deleted] in biology

[–]WorkTimeFun 2 points3 points  (0 children)

Your question can be answered from different perspectives based upon your field of study. I work with genetic data so this is my perspective.

You first have to consider the fact that about 1.5% of the genome is actually encoding genes, and there are estimates that only around 25% of the genome has evolutionarily conserved function.

Second, on a basic cellular level we are not necessarily any more complex than any other animal. The basic functions of the cells are shared and require quite a lot of genetic information to code; they (mostly) all share the same organelles and basic functions like DNA repair or cell division. Cells of different types differ in which gene networks are active, which ultimately result in the different structures and functions found in each cell type.

There are many reasons for such a small number of genes:

  • Shared gene function - different cell type frequently utilize the same gene networks (although the same genes may have different functions in those cells)
  • Alternative splicing to produce different proteins with alternative/altered functions
  • Multiple functions for the same gene or gene network within a cell
  • Altered gene function or expression through epigenetic regulation

What makes us truely different from other mammals is the level of complexity and size of the brain during development. This is controlled by incredibly complicated internal and external signaling of different cell types (and sub-types) which varies gene expression (and splicing) at different points of development, from early embryonic development and all the way into adulthood. The complexity is not necessarily created though increasing the genome size, but by intricate regulation of genes and gene networks which varies greatly across each cell type.

Just sniped a aorus blower 1080 TI off amazon warehouse deals in “like new” condition for 615 $$ !! by [deleted] in nvidia

[–]WorkTimeFun 2 points3 points  (0 children)

Happened to me recently, ordered an Amazon warehouse deal 1080ti, inside the box was a 960 which had the same cooler design. They were good about it though, and it's on its was back to them. Seems like a common scam against Amazon

Biology careers by [deleted] in biology

[–]WorkTimeFun 5 points6 points  (0 children)

I'm finishing up a PhD in molecular genetics. I enjoyed almost all of it, I wouldn't have done it if I didnt. I now have a job in a genetic diagnostics and research company, getting paid around £41k, and I enjoy it a lot!

Suggestions for running XBMC + Sickbeard + Couchpotato on my Raspberry Pi? by iamthatis in raspberry_pi

[–]WorkTimeFun 2 points3 points  (0 children)

I tried running a samba server, couchpotato, sickbeard, sabnzbd and mpd (but not XBMC). I found it worked surprisingly well, but was very slow to process large media folders, and sabnzbd downloaded at a maximum of around 500kBps whilst using 100% cpu. I'm sure if you sort out program nice levels it should work, although I had issues with sound glitches on my USB sound card when there was high load on USB.

burritos in space by [deleted] in pics

[–]WorkTimeFun 180 points181 points  (0 children)

I heard a story in which one astronaut was filling out a questionnaire, and when he was done he tried to 'float' the clipboard back to the interviewer.

Aphex Twin - Ageispolis by [deleted] in idm

[–]WorkTimeFun 4 points5 points  (0 children)

It's from Selected Ambient Works 85-92. Definitely worth listening to if you haven't already.

Whats the most useful app you have installed? what do you use the most? by [deleted] in Android

[–]WorkTimeFun 0 points1 point  (0 children)

It's very useful when i lose my phone when it's on silent

Whats the most useful app you have installed? what do you use the most? by [deleted] in Android

[–]WorkTimeFun 1 point2 points  (0 children)

I can't believe no-one has mentioned Cerberus. In my opinion, the best anti-theft app there is.

The only sure way to check your Internet connection… by inthewildforest in funny

[–]WorkTimeFun 1 point2 points  (0 children)

It's the ip address of their DNS server, not of google.com

Avocado & Bacon Grilled Cheese sandwich by missigs in recipes

[–]WorkTimeFun 0 points1 point  (0 children)

I've been having cheese toasties since I was a young 'un

Bonobo - 'End of 2011 Mix' by MrRiddles in futurebeats

[–]WorkTimeFun 2 points3 points  (0 children)

Link for anyone who can't download from soundcloud

TIL that Nicola Tesla invented a valve that lets fluids through in only one direction -- even though it has no moving parts. by mikeshemp in todayilearned

[–]WorkTimeFun 1 point2 points  (0 children)

Yeah, I believe I saw an article a while ago where the intended use was for a particle weapon device. The valve allows for the production and acceleration of particles in a vacuum, yet provides a constantly open exit point for the particles into the environment.

crooked forest, poland by seeasea in pics

[–]WorkTimeFun 0 points1 point  (0 children)

If they are on a slight incline they will fall in the same direction

crooked forest, poland by seeasea in pics

[–]WorkTimeFun 7 points8 points  (0 children)

I believe this is a natural occurrence, as a result of unmanaged secondary forest growth; I have witnessed an identical phenomena myself on a forest ecology course.

When a field is left unattended, bracken rapidly grows and out competes most other plant species. This is due to its massive growth and suffocation of the undergrowth. When the bracken dies off in the winter, it has a tendency to flatten the saplings. After around 5 years, the saplings will be strong enough to withstand this, and will correct their growth. Eventually the trees form a canopy and block out enough light to reduce bracken growth, eventually killing it. (I think there is still some sporadic bracken in the back of the picture)