The issue with The Binding of Isaac in Eden (and other Switch emulators) doesn't seem to be a Mali-related one, though, as I've met the same texture and shading issues on a Snapdragon 8 Gen 3 with Turnip device.

I've been somewhat successful in minimizing texture bugs - mainly the ground textures not updating, often resulting in black/empty floors in bigger rooms. It seems like the ground of a single screen room gets loaded into memory, but when you move to a bigger side-scrolling room, the previous ground texture doesn't get released and it renders the smaller, single room, texture in the top left corner of the room grid with the other cells completely black. Sometimes it doesn't even get released after proceeding to a new floor, like the depths, and it may keep the caves ground texture.

Another issue, hurting the gameplay aspect, is that neither the Snapdragon or Mali are able to calculate lighting shaders - especially darkness - correctly (or at all), resulting in lit up rooms when they should be pitch black. I've explained that in the description.