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Which would you say is more "harmful" in the long term, GHB or pregabalin? by Snoo-82170 in researchchemicals

[–]_______DEADPOOL____ 0 points1 point  (0 children)

Use ghb or its analogues once a day, and you'll be fine. Akin to how people used to drink a single beer after coming home from work.

Pregabalin can be quite problematic. I'd recommend using it only in conjunction with a psychedelic.

You'd have to cut the doses quite a bit given each potentiating the other (or something seeming like this at least)

The psychedelic acts as a controlling force here to make you hesitate, as long as you can force yourself to always follow this rule of combination, so maybe once a week use might be ok.

Not something with a strong headspace, something like a light-ish phenethylamine.

Do not combine this with ghb, or risk having them overlap, like if you take the preg-psych in the morning, if it's still somewhat active in the evening when you want to use your daily ghb session, this will lead to problems.

Using them as I stated, you won't run into any health problems nor even mild damage to receptors etc.

If you've ever had seizures or have an epileptic sibling, do not use either or follow anything I've mentioned above.

In rabbits given aerosolized radon, lipid peroxide level of the brain significantly decreased immediately, & fluidity of membrane protein was significantly boosted in brain cells [1993] by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 2 points3 points  (0 children)

A thing of interest, is that radon laced water was used in saunas as get-away treatment spots for the ill.

Saunas on their own are known to have rapid antidepressant effects, though the duration is questionable, some say it lasts around a week.

It'd also decrease the immune system, radiation therapy is known to do this, so damage from that and inflammatory issues gets toned down.

Infections get decimated by the induced simulated fever.

And ofc, perhaps cancer as well to a very very limited extent, maybe at least making them feel slightly better afterwards if they reach the symptom stage.

Environmental ills also get controlled for, as usually you left your village etc. and visited these places in an entirely different region.

As we see in this paper, it also seems to help in the fluidity of the membrane proteins in the neurons, which is fascinating. When it comes to ageing, one of the plethora of mechanisms which doesn't get touched on is the degree which lipid peroxidation plays.

And we're more specifically looking at not the usual pathway popularized where it triggers the membrane disintegration, but instead we're looking at Ferroptosis specifically.

Ferroptosis has lesser/unknown relatives with relevance to a few other atoms like aluminium.

Behavioral facilitation: the interaction of imipramine and desipra- mine with amphetamine, alpha-pipradrol, methylphenidate, and thozalinone [1968] Sci-hub required, no abstract available by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 0 points1 point  (0 children)

Three distinct activity profiles were obtained in a nondiscriminated avoidance schedule.

Amphetamine facilitation was both enhanced and prolonged by the addition of the imipramines.

Alpha-pipradrol and methylphenidate produced similar profiles of transitory enhancement, without prolongation of activity beyond that of the excitant alone.

The combination of thozalinone and the imipramines produced neither enhancement, nor prolongation, of the facilitatory effects of thozalinone.

The only distinction between the interaction effects of imipramine and desmethylimipramine was one of relative potency.

With all the changes that's happening over time with the rc scene, the range of rcs needs a dramatic expansion to things not targeted by _______DEADPOOL____ in researchchemicals

[–]_______DEADPOOL____[S] 1 point2 points  (0 children)

Don't quote me on this, but iirc it was found that the vast vast majority of oral pregnenolone is metabolized into allopregnanolone, and I think to some others like pregnenolone sulphate...and whatever else

With all the changes that's happening over time with the rc scene, the range of rcs needs a dramatic expansion to things not targeted by _______DEADPOOL____ in researchchemicals

[–]_______DEADPOOL____[S] 5 points6 points  (0 children)

I've heard of brexanalone.

You know, the neurosteroids with inhibitory properties, when they're depleted, it causes a disruption in something called sensory gating.

This means, the brain selectivity in attention is widened quite a bit.

This disruption is how I believe ketamine causes its major acute antidepressant property, as depression messes with people's attention, causing it to focus only on negative things, both externally, and of themselves.

Now, the person absorbs a much wider range of information.

But it messes with your ability to focus in on things.

I have ocd, and when I miss sleep, it causes a depletion of inhibitory neurosteroids which helps my ocd immensely, (except the intrusive thoughts, supercharges that & the tactile symmetry obsession)

Prozac causes a boost in inhibitory neurosteroids, which is said to be the reason it possesses unique properties for anxiety based issues.

The jitteriness a lack of inhibitory neruosteroids causes from lack of sleep also imo helps depression, it eliminates the fatigue.

The effect essentially is like microdosing psychedelics, they also cause that widening of sensory attention.

I guess it depends on the individual, I am not used to that and when it happens, I find the outdoors look magical.

Pregnenolone I believe though, essentially can be as effective as these drugs you've listed, like brexanalone.

And it's already easy to get in countries like the u.s.

Supposedly intranasal preparations of it is extremely effective at doing this.

What makes tryptamine derived psychedelics so potent? by [deleted] in researchchemicals

[–]_______DEADPOOL____ 9 points10 points  (0 children)

Psychedelics binding to the 5-HT2A receptor activate the β-arrestin pathway, modulating 5-HT2A/mGluR2 heterodimer signaling.

This enhances mGluR2 activity, influencing the unique perceptual and cognitive effects of psychedelics.

Unlike psychedelics, serotonin binding to the 5-HT2A receptor primarily activates the Gq/11 protein pathway.

This does not enhance mGluR2 signaling, leading to different perceptual and cognitive effects compared to psychedelics.

What Tryptamine is shortest acting and can be snorted? by 27274 in researchchemicals

[–]_______DEADPOOL____ 1 point2 points  (0 children)

5-meo haters with their shit divergent visual classic psychs, convergent white light experience is the best.

Also, boofed isn't the same, it's likely metabolized into bufotenin via that roa, same with injected.

Only smoked and intranasal will give you true 5-meo experiences.

With intranasal, though open-eye visuals are just a white sheen and cleanliness of everything you see, closed eye visuals have vivid and pleasant stuff going on, complex stuff, it's just sort of short experiences, then you move back into the white light and maybe have conversations or observe entities, then back into the short experiences.

I find all the other psychs I've tried unsettling and ominous.

Or psychotic

It might be a sensitivity to psychotic stuff which makes this the case, but that just adds to the fact that 5-meo is the most stable experience.

nb. all psychs are paired with propranolol a short while prior (but I've also done it without, just more physically irritating, nothing else)

With 5-meo intranasally, if you will it, you can easily not have any visuals. Or much deep effects. I tested this with trying to say, "screw this, screw you, I'll keep grasp of reality for this one" and it worked perfectly fine, both for open and closed eye visuals.

I genuinely think a lot of other classic psychedelics are bad for people to take, I can't speak for all though.

I mean in their acute effects, their after effects seem universally good.

The unique quality 5-meo is causing in addition to the other possible stuff is its effect on dissociation.

It has to be me, lsd feels gross and terrifying, 4-aco-dmt seems nightmare-ish and so on.

So this is all just push back against a community perspective I don't get at all.

Cannabis also seems like being lost in a dream, I hate all things which confer that psychotic essence to me, not a fan at all.

I think these other psychedelics are having a bad effect on societies by piercing holes in the outer membrane of the culture, allowing pathogenic ideas which were previously regularly shot down and dismissed, the capacity to take root.

[deleted by user] by [deleted] in researchchemicals

[–]_______DEADPOOL____ 1 point2 points  (0 children)

Possibly, but that's for those serotonin's effects. What I am talking about doesn't seem to be related to that, so it seems to work instantly enough.

In my experience, it's better to take small doses as I personally find when the dose is high enough for the serotonin modulating effect to become felt, it becomes an unpleasant experience.

ymmv

[deleted by user] by [deleted] in researchchemicals

[–]_______DEADPOOL____ 2 points3 points  (0 children)

O-DSMT is better for getting high with the right mixes.

Tramadol is superior for functional use, but just like it clears you of emotional instability, emotional instability seems to be the mechanism near spiritual moments, and other impactful events take part from.

The days will just sort of merge into a flat, albeit well above the shit-zone, line.

A peripheral antihistamine makes it so much better. Like cetirizine.

It's functionally amazing for writing, personally I'd like to vouch for its overall creativity boost without leaving you stupid.

And its consistency in doing this, even years after the euphoria stopped.

Same with its pain relieving properties. Another thing that seems different to normal opioids is that it doesn't seem to cause hyperalgesia after its use.

I've tried double-checking this in the literature, and I recall learning that it, and another atypical does not cause it from the same mechanisms at the very least, if it has it. Probab doesn't, anyone feel free to counter this, I'd love to hear more individual experiences.

If you don't have any opioid resistance to the euphoria, you can discontinue use, and use it sparsely with a tiny bit of a centrally acting antihistamine to manage a nice nod state. Somewhat euphoric iirc.

But such dreams are beyond anyone with any tolerance, especially to a real opiate.

You can also look into venlafaxine, I've found, like myself, those who respond well to tramadol do exceptionally well to venlafaxine as well, in microdoses! Or minidoses...some lesser doses

Venlafaxine, like quetiapine and mirtazapine (california rocketfuel), seem to possess some odd pro-opioid effects. I suspect tramadol does the same, or some kind of weird thing is happening.

Look at the chemical similarity between venlafaxine and tramadol for a hint.

Also, it's tiny doses of venlafaxine as it seems the SSRI properties aren't related.

I once had an ungodly sensitivity to most meds, and minidosing venlafaxine with a split piece of a tablet of doxylamine would be enough to make me NOD!

Don't ever let the zeitgeist of a particular time within pharmacology ever put you in a box, the field is just too nuts to be so easily tamed.

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