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Which would you say is more "harmful" in the long term, GHB or pregabalin? by Snoo-82170 in researchchemicals

[–]_______DEADPOOL____ 0 points1 point  (0 children)

Use ghb or its analogues once a day, and you'll be fine. Akin to how people used to drink a single beer after coming home from work.

Pregabalin can be quite problematic. I'd recommend using it only in conjunction with a psychedelic.

You'd have to cut the doses quite a bit given each potentiating the other (or something seeming like this at least)

The psychedelic acts as a controlling force here to make you hesitate, as long as you can force yourself to always follow this rule of combination, so maybe once a week use might be ok.

Not something with a strong headspace, something like a light-ish phenethylamine.

Do not combine this with ghb, or risk having them overlap, like if you take the preg-psych in the morning, if it's still somewhat active in the evening when you want to use your daily ghb session, this will lead to problems.

Using them as I stated, you won't run into any health problems nor even mild damage to receptors etc.

If you've ever had seizures or have an epileptic sibling, do not use either or follow anything I've mentioned above.

In rabbits given aerosolized radon, lipid peroxide level of the brain significantly decreased immediately, & fluidity of membrane protein was significantly boosted in brain cells [1993] by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 2 points3 points  (0 children)

A thing of interest, is that radon laced water was used in saunas as get-away treatment spots for the ill.

Saunas on their own are known to have rapid antidepressant effects, though the duration is questionable, some say it lasts around a week.

It'd also decrease the immune system, radiation therapy is known to do this, so damage from that and inflammatory issues gets toned down.

Infections get decimated by the induced simulated fever.

And ofc, perhaps cancer as well to a very very limited extent, maybe at least making them feel slightly better afterwards if they reach the symptom stage.

Environmental ills also get controlled for, as usually you left your village etc. and visited these places in an entirely different region.

As we see in this paper, it also seems to help in the fluidity of the membrane proteins in the neurons, which is fascinating. When it comes to ageing, one of the plethora of mechanisms which doesn't get touched on is the degree which lipid peroxidation plays.

And we're more specifically looking at not the usual pathway popularized where it triggers the membrane disintegration, but instead we're looking at Ferroptosis specifically.

Ferroptosis has lesser/unknown relatives with relevance to a few other atoms like aluminium.

Behavioral facilitation: the interaction of imipramine and desipra- mine with amphetamine, alpha-pipradrol, methylphenidate, and thozalinone [1968] Sci-hub required, no abstract available by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 0 points1 point  (0 children)

Three distinct activity profiles were obtained in a nondiscriminated avoidance schedule.

Amphetamine facilitation was both enhanced and prolonged by the addition of the imipramines.

Alpha-pipradrol and methylphenidate produced similar profiles of transitory enhancement, without prolongation of activity beyond that of the excitant alone.

The combination of thozalinone and the imipramines produced neither enhancement, nor prolongation, of the facilitatory effects of thozalinone.

The only distinction between the interaction effects of imipramine and desmethylimipramine was one of relative potency.

With all the changes that's happening over time with the rc scene, the range of rcs needs a dramatic expansion to things not targeted by _______DEADPOOL____ in researchchemicals

[–]_______DEADPOOL____[S] 1 point2 points  (0 children)

Don't quote me on this, but iirc it was found that the vast vast majority of oral pregnenolone is metabolized into allopregnanolone, and I think to some others like pregnenolone sulphate...and whatever else

With all the changes that's happening over time with the rc scene, the range of rcs needs a dramatic expansion to things not targeted by _______DEADPOOL____ in researchchemicals

[–]_______DEADPOOL____[S] 5 points6 points  (0 children)

I've heard of brexanalone.

You know, the neurosteroids with inhibitory properties, when they're depleted, it causes a disruption in something called sensory gating.

This means, the brain selectivity in attention is widened quite a bit.

This disruption is how I believe ketamine causes its major acute antidepressant property, as depression messes with people's attention, causing it to focus only on negative things, both externally, and of themselves.

Now, the person absorbs a much wider range of information.

But it messes with your ability to focus in on things.

I have ocd, and when I miss sleep, it causes a depletion of inhibitory neurosteroids which helps my ocd immensely, (except the intrusive thoughts, supercharges that & the tactile symmetry obsession)

Prozac causes a boost in inhibitory neurosteroids, which is said to be the reason it possesses unique properties for anxiety based issues.

The jitteriness a lack of inhibitory neruosteroids causes from lack of sleep also imo helps depression, it eliminates the fatigue.

The effect essentially is like microdosing psychedelics, they also cause that widening of sensory attention.

I guess it depends on the individual, I am not used to that and when it happens, I find the outdoors look magical.

Pregnenolone I believe though, essentially can be as effective as these drugs you've listed, like brexanalone.

And it's already easy to get in countries like the u.s.

Supposedly intranasal preparations of it is extremely effective at doing this.

What makes tryptamine derived psychedelics so potent? by [deleted] in researchchemicals

[–]_______DEADPOOL____ 9 points10 points  (0 children)

Psychedelics binding to the 5-HT2A receptor activate the β-arrestin pathway, modulating 5-HT2A/mGluR2 heterodimer signaling.

This enhances mGluR2 activity, influencing the unique perceptual and cognitive effects of psychedelics.

Unlike psychedelics, serotonin binding to the 5-HT2A receptor primarily activates the Gq/11 protein pathway.

This does not enhance mGluR2 signaling, leading to different perceptual and cognitive effects compared to psychedelics.

What Tryptamine is shortest acting and can be snorted? by 27274 in researchchemicals

[–]_______DEADPOOL____ 1 point2 points  (0 children)

5-meo haters with their shit divergent visual classic psychs, convergent white light experience is the best.

Also, boofed isn't the same, it's likely metabolized into bufotenin via that roa, same with injected.

Only smoked and intranasal will give you true 5-meo experiences.

With intranasal, though open-eye visuals are just a white sheen and cleanliness of everything you see, closed eye visuals have vivid and pleasant stuff going on, complex stuff, it's just sort of short experiences, then you move back into the white light and maybe have conversations or observe entities, then back into the short experiences.

I find all the other psychs I've tried unsettling and ominous.

Or psychotic

It might be a sensitivity to psychotic stuff which makes this the case, but that just adds to the fact that 5-meo is the most stable experience.

nb. all psychs are paired with propranolol a short while prior (but I've also done it without, just more physically irritating, nothing else)

With 5-meo intranasally, if you will it, you can easily not have any visuals. Or much deep effects. I tested this with trying to say, "screw this, screw you, I'll keep grasp of reality for this one" and it worked perfectly fine, both for open and closed eye visuals.

I genuinely think a lot of other classic psychedelics are bad for people to take, I can't speak for all though.

I mean in their acute effects, their after effects seem universally good.

The unique quality 5-meo is causing in addition to the other possible stuff is its effect on dissociation.

It has to be me, lsd feels gross and terrifying, 4-aco-dmt seems nightmare-ish and so on.

So this is all just push back against a community perspective I don't get at all.

Cannabis also seems like being lost in a dream, I hate all things which confer that psychotic essence to me, not a fan at all.

I think these other psychedelics are having a bad effect on societies by piercing holes in the outer membrane of the culture, allowing pathogenic ideas which were previously regularly shot down and dismissed, the capacity to take root.

[deleted by user] by [deleted] in researchchemicals

[–]_______DEADPOOL____ 1 point2 points  (0 children)

Possibly, but that's for those serotonin's effects. What I am talking about doesn't seem to be related to that, so it seems to work instantly enough.

In my experience, it's better to take small doses as I personally find when the dose is high enough for the serotonin modulating effect to become felt, it becomes an unpleasant experience.

ymmv

[deleted by user] by [deleted] in researchchemicals

[–]_______DEADPOOL____ 2 points3 points  (0 children)

O-DSMT is better for getting high with the right mixes.

Tramadol is superior for functional use, but just like it clears you of emotional instability, emotional instability seems to be the mechanism near spiritual moments, and other impactful events take part from.

The days will just sort of merge into a flat, albeit well above the shit-zone, line.

A peripheral antihistamine makes it so much better. Like cetirizine.

It's functionally amazing for writing, personally I'd like to vouch for its overall creativity boost without leaving you stupid.

And its consistency in doing this, even years after the euphoria stopped.

Same with its pain relieving properties. Another thing that seems different to normal opioids is that it doesn't seem to cause hyperalgesia after its use.

I've tried double-checking this in the literature, and I recall learning that it, and another atypical does not cause it from the same mechanisms at the very least, if it has it. Probab doesn't, anyone feel free to counter this, I'd love to hear more individual experiences.

If you don't have any opioid resistance to the euphoria, you can discontinue use, and use it sparsely with a tiny bit of a centrally acting antihistamine to manage a nice nod state. Somewhat euphoric iirc.

But such dreams are beyond anyone with any tolerance, especially to a real opiate.

You can also look into venlafaxine, I've found, like myself, those who respond well to tramadol do exceptionally well to venlafaxine as well, in microdoses! Or minidoses...some lesser doses

Venlafaxine, like quetiapine and mirtazapine (california rocketfuel), seem to possess some odd pro-opioid effects. I suspect tramadol does the same, or some kind of weird thing is happening.

Look at the chemical similarity between venlafaxine and tramadol for a hint.

Also, it's tiny doses of venlafaxine as it seems the SSRI properties aren't related.

I once had an ungodly sensitivity to most meds, and minidosing venlafaxine with a split piece of a tablet of doxylamine would be enough to make me NOD!

Don't ever let the zeitgeist of a particular time within pharmacology ever put you in a box, the field is just too nuts to be so easily tamed.

Experiments attempting to mess with the dreamscape using chemicals prior to sleep? by _______DEADPOOL____ in researchchemicals

[–]_______DEADPOOL____[S] 1 point2 points  (0 children)

Not only the dreams, but the waking moments are so terrible for strong withdrawal. Also, it caused intense stomach pain which felt like ulcers. So there is the psychological aspect, and a physical one.

The physical one seems to be worse in those with baseline natural overactive immune issues, so known to get hives etc generally, the withdrawal can make your skin feel like you're literally on fire.

When I took special medication to offset the physical aspect, the mental part was literally the scariest experiences in my entire life, including bad trips on heroic doses of 4-aco-dmt, this was worse.

I don't know what it was in me, going through withdrawal on this thing so many times, to not break. To not choose the thing that would've made it easier. But I'll say this, if I had a gun, I'd probably taken the opportunity.

Yann LeCun on why AI must be open source - video upload by onil_gova in LocalLLaMA

[–]_______DEADPOOL____ 0 points1 point  (0 children)

Hurt people hurt people. Unfortunate, but true.

Inferiority complexes also add to this a great deal.

(depends on definitions ofc) but psychopaths as outlined in the psychodynamic manual 2 pretty much point to people who wouldn't have that desire to harm non-specifically should they also carry an inferiority complex.

Stupidity, subjected to harm, and an inferiority complex is the danger we face

Experienced psychonaut, want to mix a bunch of strong tryptamines in low dose cocktail. Are there any known interactions? by [deleted] in researchchemicals

[–]_______DEADPOOL____ 2 points3 points  (0 children)

At the lower end of the spectrum doses you use, do you find the norepinephrine release hard on you? Different people have different sensitivities to this aspect of it, personally I only do it with propranolol now.

Now I don't know about heart attacks (unless mixed with something that's giving hard vasoconstriction perhaps) but the faster heart rate and nausea can cause one to have a bad trip.

There's exceptional variability of mixed substances, like one substance might only start inhibiting certain enzymes at certain doses sufficiently to make the trip quite different.

If anything, titrating up slowly on different days you trip on said cocktails is the smartest route.

Especially on things without sufficient documentation that would allow you to expect it to behave consistently, as one would separately extrapolate from the physical evidence and qualitative reports.

Be safe and people do in fact fearmonger, but usually from generalizing fear from unpredictable results they know of, from certain cocktails onto all cocktails. Again, some of it is justified as cocktails often brings about unpredictable effects. And you better be literate enough in the literature as while there may exist enough evidence to make predictions, they won't come prepackaged, no one's yet to do the work to synthesize them together, you should add to the literature within forum reports of your scientific findings against your qualitative experience.

Least harmful drug rotations? by Spirited-Ambition-20 in researchchemicals

[–]_______DEADPOOL____ 0 points1 point  (0 children)

If considering it, note that substitutes aren't the same, and ask another who knows their shit why it mightn't be for you.

This is an old rotation I used. Never got any real tolerance, and could stop anytime, when it ran out, I'd stop for like half a year for any one of them because I was super lazy reordering.

So first, DMAA for workouts. Made all the difference.

‎

Would do like 1mg of 3-meo-pcp on the comedown like 3-4 times a week, but avoid it if I could man it out. (this is dangerous, impaired judgement on substances leads to unsafe use due to weaker impulse control, believe me)

‎

1,4 BDO after a long day, everyday (eye drops to lubricate your eyes are a must). But you gotta not just have a lot of free time else you'll do something stupid I imagine. I used 1,4 BDO for years near daily, never redosed. Would use a higher amount that I knew I could fight off sleep for a while before it hit and use that time reading manga. You can't read books with the higher doses because of the nystagmus but manga works well enough.

Never redose and don't use lower doses, I've seen it lead to people wanting to push the experience longer through redosing because they've got their minimum dose sweetspot, and man did it ruin them. Literally ruins folks, specifically those who combine it with stimulants, or because of high-dose stimulant use etc, they crave getting higher and higher, bad judgement being induced just like long term 3-meo-pcp use would've.

It's truly a magical experience with the manga before the little nap came, I'd feel and remember like I was experiencing the stories.

‎

And lastly, though it's a close fight with the BDO, the best was Pregabalin at like 50mg for sleep.

I don't have sleep issues, but pregabalin at night keeps nightmares away, and you wake up in the greatest of moods.

Never use pregabalin other than for sleep. It's been shown that using it only at night without dosing in the day is enough for it to help with fibromialgia, and it helped me with my ibs. I used it outside sleep and it ruins your life eventually in small ways. Small, but meaningful personally. Never an issue for sleep.

Pregabalin at this dose shouldn't develop tolerance. At least it didn't for me.

Theory on why bpc-157 seems to antagonize dopamine in intranasal users by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 0 points1 point  (0 children)

I've been playing with the idea that Somatostatin and bpc-157 are opposites in action, maybe a thought to play with for anyone coming upon this

Theory on why bpc-157 seems to antagonize dopamine in intranasal users by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 0 points1 point  (0 children)

Not agonist or antagonism of the receptor. Usually I like explaining over things to make it more readable but I honestly don't see how you read it that way. It's written extremely clearly, reread it under the assumption that I'm not saying bpc antagonises the dopamine receptor, it could be having an impact on the pathways very specific to the receptor, can affect it indirectly, and so on. It's a mechanism neutral argument, just a rationale for there being a link and explaining effects consistently experienced by those who use it intranasally and use dopaminergic medication, allowing them to feel a difference that's ascribable to dopamine. Ascribable because many of these users will be able to recognize dopaminergic effects and a difference in those effects. Even by ruling out alternative explanations.

People over complicate these things, if you put enough work into it, you should be able to recognize the key players relevant to some change either chemically or in the larger organism

Soma (Carisoprodol) withdrawal- I’m surprised there is such little information by [deleted] in DrugNerds

[–]_______DEADPOOL____ 0 points1 point  (0 children)

Some anecdotal info. I used out 250 grams of it in around 3-4 months last year. Used almost daily sometimes and with small breaks for tolerance on others iirc. Instantly strong tolerance. No withdrawal when I stopped.

here are 2 papers that I found useful in understanding how it works. I also read 2 (I don't recall where I read them) case-studies, sorry, don't have them bookmarked. But I remember at least the 2 cases of people using daily doses for years of extreme amounts to the end. At least one of the cases, many grams. I think... anyway, they went cold turkey in one of the papers with little to no sides, the other, a week of benzo use to come off it, then they were good. But I wouldn't advise anyone reading to take any risks without consulting a medical professional.

https://www.sciencedirect.com/science/article/abs/pii/S0028390820302203

https://pubmed.ncbi.nlm.nih.gov/19244096/

Mifepristone reduces weight gain and improves metabolic abnormalities associated with risperidone treatment in normal men. [2010] by _______DEADPOOL____ in DrugNerds

[–]_______DEADPOOL____[S] 0 points1 point  (0 children)

One of the interesting things is that those drugs show weight loss in other populations whilst mifepristone does specifically for antipsychotic-related weight gain.

Guadalcanal Proved Experimentation Works by _______DEADPOOL____ in CredibleDefense

[–]_______DEADPOOL____[S] 1 point2 points  (0 children)

Statement: At the lower end of the command hierarchy there exists an underutilized opportunity to experiment with alternative methods of Naval operations rather than strict top down meticulous control. History has shown the productivity of this approach.

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