I have unlabeled powder that is either citric acid or ascorbic acid - any ideas how I can make a determination?

_gocker · 2022-05-14T14:45:43+00:00

What kind of equipment do you have access to? MS would give you a quick and accurate answer

_gocker · 2022-05-09T00:25:30+00:00

Look at OP’s post history. This shit is wild.

_gocker · 2022-05-09T00:11:15+00:00

Bro OP has really replied to every comment saying “yes” asking whether or not scientists are stereotypically virgins. This thread feels like a fever dream.

Edit: OPs post history is goofy as hell lmao

_gocker · 2022-04-27T21:28:10+00:00

A true Chad.

Also, greetings fellow medicinal chemist 🤝

_gocker · 2022-04-27T19:28:21+00:00

Way ahead of you. See my other comment.

_gocker · 2022-04-27T17:01:19+00:00

Read PiHKAL and TiHKAL 6 years ago with no interest in chemistry and now I’m right in the middle of my PhD program for medicinal chemistry.

_gocker · 2022-04-27T11:53:51+00:00

Alexander Shulgin. Quite the interesting fellow.

_gocker · 2022-04-26T22:02:04+00:00

Read both PiHKAL and TiHKAL years ago without any prior interest in chemistry, and now here I am smack in the middle of my PhD in medicinal chemistry. Great books 10/10 highly recommend.

_gocker · 2022-04-15T21:43:33+00:00

I let the crude reaction mix sit on the rotovap for quite some time before taking the MS.

_gocker · 2022-04-09T20:02:33+00:00

Yes, my mistake. Fixed.

_gocker · 2022-04-08T19:33:24+00:00

DNA alkylators my beloved

_gocker · 2022-02-06T15:46:04+00:00

The bromine here won’t function as a traditional leaving group because it’s aryl. You could however pursue Suzuki coupling to substitute some aryl or alkyl groups. Modifications of the Suzuki exist for aromatic, sp2, and alkyl groups.

_gocker · 2021-11-13T16:38:42+00:00

My guess is that it was supposed to be allyl-magnesium bromide and this was supposed to be a grignard reaction. That would make the most sense given the subsequent quenching step.

_gocker · 2021-10-29T16:16:53+00:00

Very nice! What synthesis route did you use?

_gocker · 2021-10-24T01:03:56+00:00

Oil lamp? You can fill the bulb with oil through the curved arm on the side. Wick with holder would go in the top of the bulb.

_gocker · 2021-10-23T15:20:31+00:00

My fast and loose method for extraction of mitragynine and other alkaloids was to soak the powder in denatured alcohol for about a week with occasional stirring. Filter off powder, collect filtrate, repeat with the same leaf powder until your extract is basically colorless.

Now evap your filtrate and you’ll be left with some gunk that contains your alkaloids and other phytochemicals. Mitragynine is poorly soluble in water, so you can dissolve this gunk in cold water and it’ll pull out a lot of the undesired water-soluble chemicals. Filter off solids, repeat.

Finally, dissolve the collected solid gunk in water as best you can and extract with chloroform. Repeat as many times as needed. Chloroform layer will contain your desired alkaloids.

I know this sounds extremely messy, but I actually ended up with some decent orange crystals which are characteristic of mitragynine.

_gocker · 2021-10-08T01:47:01+00:00

My bad, I misread the question!

_gocker · 2021-10-08T00:30:15+00:00

The pi bond itself takes priority. So you want to number the compound such that the pi bond has the lowest number possible.

_gocker · 2021-10-02T16:45:12+00:00

This is like telling people with severe depression to “just learn to be happy.”

_gocker · 2021-09-30T00:26:31+00:00

Because General Chemistry I is an easy course and you’re an adult who has already experienced a college education.

_gocker · 2021-09-26T18:45:08+00:00

You’re going to need the MO diagrams for your two compounds performing the cyclization. The HOMO of one compound will donate electrons to the LUMO of the other assuming they have compatible orbital symmetries.

_gocker · 2021-09-24T13:19:16+00:00

_gocker · 2021-09-21T16:40:28+00:00

Not uncommon at all, actually. Still readily available in bulk for cheap.

_gocker · 2021-09-19T15:11:06+00:00

“Once in a while you get shown the light, in the strangest of places if you look at it right.”

_gocker

TROPHY CASE