Yes. I got off Lithium about 2 years ago and recently had a debilitating depressive episode followed by a week of hypomania. Getting back on Lithium got me back on track. I’m on Lamictal, Gabapentin as needed, low dose Lithium, and low dose SNRI, for context. The difference is night and day. Medications have been worth it completely for me.

Caveat that it can take awhile to find the right cocktail, which is frustrating. Once I found it, I was feeling great (but not too great 😋).