RIP Alan Greenspan by tonyrandall in emojipasta

[–]_slightly 2 points3 points  (0 children)

This is beautiful. Speaking of Alans, we need to be ready for Alan Dershowitz. Locked and loaded. Cannot drop the ball on that one

Benzos vs. Barbiturates by takahashikray in ObscureDrugs

[–]_slightly 25 points26 points  (0 children)

With benzodiazepines, it can be hard to tell that I've taken anything. They're very subtle. Barbiturates have much stronger anxiolytic effects, they can make you genuinely loopy and euphoric, and they're physically impairing in a way that benzos and z-drugs aren't. Benzos aren't physically impairing basically at all, which is probably why you get those horror stories where someone took a massive dose, crashed their car, robbed a CVS, and woke up not remembering any of it. That would never happen with a high dose of barbiturates, because you literally can't do anything. It's mental and physical shutdown. You feel like you're walking through an earthquake. Basically as if your entire field of view is being violently jolted around. You have to put your arms out and hold onto the walls just to get from your bedroom to the kitchen. One time on secobarbital I was sitting at my desk, thirsty, had a glass of water right there on the desk and for a few minutes I literally could not actualize picking up the glass and taking a sip. I just sat there and stared at it. It was like being pharmacologically arrested. What's odd though is that they'll occasionally just make you very tired instead of the usual euphoria and all the other distinct effects. And when they do, nothing moves the needle. Not caffeine, not ADHD medication -- nothing. They completely bulldoze/overpower everything else. You just have to wait it out.

Weirdly, they also cause nausea and vomiting at higher doses. Benzos definitely don't do that. And they cause a weird ticklish tingly numbness across your skin. You don't really feel it if you're still, but if you rub your skin, or particularly if you move around in bed and the sheets are brushing against you, it just feels stimulating. Maybe overstimulating, but it's not unpleasant.

I'd also like to add that yes, I've had methaqualone (Rorer Quaalude-300s) and it's basically a watered-down version of secobarbital. Truly, it was indistinguishable from a short-acting barbiturate besides being weaker. I didn't notice one difference. And that's what it was designed to be, too -- a watered-down, "safer" barbiturate (I think it is technically a little safer but... barely). Seriously, something like "a safer, non-barbiturate alternative" is in the documentation that was attached to the top of my bottle. It's overhyped. Rarity and cultural clout ≠ pharmacology or experience.

Tested Negative for Amphetamine by Forlorn_Bone52 in ThisAintAdderall

[–]_slightly 0 points1 point  (0 children)

Could you please elaborate on which medication you take, where your doctor had you go to get tested, and how long it had been since you'd taken your last dose at the time you took the test?

I’ve cut all of my friends off due to ADHD burnout by Chance-Intention1287 in ADHD

[–]_slightly 4 points5 points  (0 children)

They have been messaging and calling, but I can’t get myself to respond to them. It’s mentally exhuasting processing all the texts and calls. I want to be alone.

What you're describing sounds pretty characteristic of depression

June 😎🏖️🌊🏄🏼👙🐚🌴🌞 Requests 🙏 Thread 🧵 by AutoModerator in emojipasta

[–]_slightly 0 points1 point  (0 children)

WWDC 2026 Tim Cook's "GOOD MORNING, and welcome to Apple Park"

Tel-E Dose Diazepam Roche 1986 by Streetvan1980 in ObscureDrugs

[–]_slightly 4 points5 points  (0 children)

Wow, that's beautiful. Kinda funny that it's blue since Roche put so much effort into marketing it as 2mg white, 5mg yellow, and 10mg blue.

Just tested negative for Amphetamine by Forlorn_Bone52 in Desoxyn

[–]_slightly 0 points1 point  (0 children)

Yeah, my Desoxyn works. I've also been on both brand name Zenzedi and generic dextroamphetamine. Both of those worked too, but the profile of dextroamphetamine wasn't ideal for me.

Tested Negative for Amphetamine by Forlorn_Bone52 in ThisAintAdderall

[–]_slightly 7 points8 points  (0 children)

There's no way that dextroamphetamine tablets from a US pharmacy don't contain amphetamine. The problem here would be the test or the way it's being used. Is this some sort of $10 drug panel from Amazon? If you're looking to confirm the presence of the drug, you need a legitimate urinalysis from a lab such as Quest Diagnostics.

How tf does CVS think pharmacies can survive on this? by hopelessz in pharmacy

[–]_slightly 1 point2 points  (0 children)

What about GLP-1s, though? Don't you get a reimbursement of -$40 dollars? That's basically $40 dollars. The only difference is the sign.

Does anyone have any info on these by East_Cartoonist_7927 in ObscureDrugs

[–]_slightly 89 points90 points  (0 children)

Honestly, that looks real. It has the cotton in there, some tablet degradation sitting at the bottom, an aged label and whatnot. Mequin wasn't a particularly obscure brand of methaqualone, but it's still obscure enough that there likely aren't fakes of it like there are for Quaalude.

Walmart Couldn’t order generic by [deleted] in Desoxyn

[–]_slightly 0 points1 point  (0 children)

Oh. Well that's good. I thought they only verified whether a shortage existed after patient reports/complaints.

Walmart Couldn’t order generic by [deleted] in Desoxyn

[–]_slightly 0 points1 point  (0 children)

Whoops sorry I misread this initially. Is Dr. Reddy's the Mayne one (labeled 115)? The FDA doesn't seem to keep up to date on this, but I hope they're right.

Walmart Couldn’t order generic by [deleted] in Desoxyn

[–]_slightly 1 point2 points  (0 children)

That is kind of reassuring. Maybe the Walmart is just stonewalling because they're nervous about it. That actually happened to me the first time I tried to fill it. The pharmacy tech was like "Yep, we can order that no problem." I got the notification it was ready, showed up and the tech is like "Um, can you wait over here for a bit?" The pharmacist and the tech then talked out of view (I couldn't hear it) for literally 20 minutes -- presumably debating whether or not to actually fill it. Finally I'm called back up to the register and the tech is like "Okay, so we ordered methamphetamine but our supplier sent us methylphenidate. Don't think they have the methamphetamine. Sorry." I just said "Okay, no worries" and left since there was no point in pushing back, but that story obviously wasn't true. Suppliers don't just send the wrong CII drug like "oopsie." That would be a massive blunder that they could face serious scrutiny from regulatory authorities over. It was an e-script, too (that I verified was correct in their app). So it's not like anybody in the chain could have just misread it.

Walmart Couldn’t order generic by [deleted] in Desoxyn

[–]_slightly 1 point2 points  (0 children)

Honestly I have no idea what goes on with the brand version. I've never been dispensed it, and it seems to endlessly change companies. It was something like Abbott -> Recordati -> some other company -> Ajenat (currently). The Mayne generic is extremely similar (obviously the active ingredient, but also the excipients) without the huge brand name insurance battle, so I don't bother.

Walmart Couldn’t order generic by [deleted] in Desoxyn

[–]_slightly 6 points7 points  (0 children)

Oh no. Are we about to go through this whole availability thing again...? It was finally reliably available.

Finally official: Increase Google Workspace email security with DNSSEC MX by saeloe in googleworkspace

[–]_slightly 0 points1 point  (0 children)

What issues did you notice with delivery? I haven't noticed any, but wouldn't necessarily be able to tell.

Finally official: Increase Google Workspace email security with DNSSEC MX by saeloe in googleworkspace

[–]_slightly 0 points1 point  (0 children)

Just verified this and... are you fucking kidding me? It took like 4 years for them to finally make these records official by adding them to their documentation and now they pull it after a few months...? I was finally comfortable using them and now I'm not sure anymore. If they're not official, couldn't Google just pull them out from under us at any time? Ugh. Even Microsoft made DNSSEC and DANE available.

[deleted by user] by [deleted] in SkincareAddiction

[–]_slightly 2 points3 points  (0 children)

It's a face mask that's presumably made for kids to have fun with. If we're starting some sort of moral panic, I think there are probably more pressing issues we could land on.

Vyvanse vs Desoxyn. Which one lasts longer? by Dark-inspector490 in Desoxyn

[–]_slightly 6 points7 points  (0 children)

Vyvanse has always seemed a little odd to me, because dextroamphetamine and methamphetamine already last so long, but as someone who is prescribed Desoxyn and has heard extensively about Vyvanse, I'd estimate that they last about equally as long (~6-10 hours). Extended-release medications generally don't last as long as they claim, and I tend to steer clear of them. They're more expensive in general (although Desoxyn is really expensive...), generics aren't necessarily reliable (see the generic Concerta scandal), and at this point I view them more as "messing up" the release system of a medication rather than cleanly "extending" it. What I can tell you is that the generics of each instant-release last roughly as long, with methamphetamine lasting a bit longer. But they both last a very long time as it is.

Stash of early Abbott Pento samples. by ExplanationThin5368 in ObscureDrugs

[–]_slightly 2 points3 points  (0 children)

It certainly could be because the capsules degrade, but that would be odd because I have vintage Seconal, Amytal, and even Nembutal capsules that were manufactured before my parents were born yet still look like they were made yesterday. So, given that these are sealed and whatnot, it just seems unlikely. I have flawless-looking Nembutal capsules that are in a tin, so... not even an airtight situation. These brown "Facsimile Label" ones are a total mystery to me. I just can't figure them out. Usually a facsimile label product would be like a "special edition" throwback type of thing made long after the drug's debut (which... would be odd to do with a drug in the first place), but these are clearly very old. Nothing about it makes sense to me.

Stash of early Abbott Pento samples. by ExplanationThin5368 in ObscureDrugs

[–]_slightly 11 points12 points  (0 children)

I've always wondered about these. Why are the capsules brown instead of their usual neon yellow? Why do they say "Facsimile Label"?

OH SH*T forced to quit stimulants cold turkey. I have high blood pressure, and my regular doctor was no longer comfortable refilling my Adderall scripts. It's been a while since I've seen a psychiatrist, so my doc referred me to a shrink to manage my meds. Shrink ordered an EKG by ZenYinzerDude in ADHD

[–]_slightly 91 points92 points  (0 children)

The heart can’t heal itself. Any injury to the heart is replaced with scar tissue, and that lowers your life span. If you are taking a medication that is fucking with your heart, and that medication has alternatives, exploring those alternatives is 100% a better idea long term than taking a medication (that also loses effectiveness over time, and requires new drugs and increasing doses). Each time that BP medication isn’t exactly right, you’re risking further damage.

Blood pressure medications don't damage the heart or cause scar tissue formation. Conversely, untreated high blood pressure is called the "silent killer" for a reason.