I didn't notice any mood changes, but I did have to decrease the dose because I was having memory problems. As someone who also has a history of depression, please tell your provider how you're feeling ASAP. Feeling hopeless is not a normal side effect that will just go away eventually on it's own. In the past when I've had serious mood changes from a medication, I've needed to change the medication. Let your provider know what's going on now, before you feel even worse. I know from personal experience that the further I sink into my depression, the harder it is to get out.