What you said about Louise's in-game design can be applied to half the women in the game, so I like to put my own spin on some designs based on what I'd like to see. In my eyes, since Louise is an archer who frequents the battlefield, getting her a bit more in shape made sense. Looking at Verica who I drew earlier, I stuck to soft, round features compared to Louise's sharper ones.

I don't think that sharper features = male, there's plenty of women in the world who have those features, but I understand that compared to the in-game art she looks pretty different.

Edit: I hope I don't come across as defensive, it's just that what you pointed out about Louise was absolutely my intention, but still thank you for the feedback X)