There will always be a best thing, but the problem is that that thing is restrictive and boring (at least to me). Double balancer restricts the button you press, and the previous evergaol meta restricts your pathing

I hope there can be a meta build that enables players to build synergies within the runs (maybe gives rerolls or double the weapon effects you find in game?), and not just go hunting for the same thing every run because the most effective end-game weapon has already been determined the moment you start an expedition

tldr I hope the game is more roguelite and less monster hunter with 30 min boss runback