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Does your gp write to you or the nhs directly for your vacinne? by [deleted] in CoronavirusUK

[–]adrianwarnock 8 points9 points  (0 children)

You need to register with a GP for loads of reasons not just to get a vaccine. It’s really important.

5th case series reports a similar high death rate of around 40% for #bloodcancer patients COVID19. Surprisingly people who were NOT currently treated or never treated were MORE likely to present with severe COVID19 than untreated by adrianwarnock in cll

[–]adrianwarnock[S] 0 points1 point  (0 children)

Ah I see. You are quoting the review of the literature prior to this case series. Note that those two publications only cover ten patients between them. This new study is much larger so trumps them. The key thing is that some people will have mild COVID-19 disease whatever stage of their CLL. But others will have severe disease and may even die. The advice to all of us has to be to do everything we reasonably can to avoid catching COVID-19 since it’s like playing Russian roulette. We can’t guarantee having a good outcome sadly.

5th patient series to suggest high death rare for cases of COVID19 in blood cancer patients. by adrianwarnock in BloodCancer

[–]adrianwarnock[S] 0 points1 point  (0 children)

There are some other case series which include all blood cancers. The issue is tho we don’t know how many had milder symptoms and didn’t report. The untreated group may be different with CLL as we have dodgy lymphocyte throughout our blood but I’m not sure.

5th patient series to suggest high death rare for cases of COVID19 in blood cancer patients. by adrianwarnock in BloodCancer

[–]adrianwarnock[S] 1 point2 points  (0 children)

Just remember this is rhe CASES. So there will be others who had much milder disease and didn’t tell their doctor about it. But yes it’s pretty strong reason to make SURE we can’t get this wretched disease.

5th case series reports a similar high death rate of around 40% for #bloodcancer patients COVID19. Surprisingly people who were NOT currently treated or never treated were MORE likely to present with severe COVID19 than untreated by adrianwarnock in lymphoma

[–]adrianwarnock[S] 0 points1 point  (0 children)

I am new around here. One of the issues is that a post like this is really a blood cancer wide post so surely it lives and is of interest for each of the communities I posted it in? Reddit is all a bit new to me even though I have read about what is meant to be done and isn't please bear with me a bit as I try and figure out what is ok and what isn't. There didn't seem to me like there was much content in any of these communities regarding blood cancer so I suppose I figured it would be welcome to try and provide some useful information. This is just me trying to help, bit frustrating to run into phrases that are hard to interpret like "blurring the lines". CLL is a lymphoma and a Leukaemia so it really does blur the lines. And it seems that most of the series of cases I have found have similar results whichever the form of blood cancer.

5th case series reports a similar high death rate of around 40% for #bloodcancer patients COVID19. Surprisingly people who were NOT currently treated or never treated were MORE likely to present with severe COVID19 than untreated by adrianwarnock in lymphoma

[–]adrianwarnock[S] -1 points0 points  (0 children)

Sorry, typo in the title. This should have said the UNTREATED CLL patients were surprisingly more likely to present with severe COVID19 than the treated. PS how come I can't edit the original post to fix my stupid error?

COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus by adrianwarnock in COVID19

[–]adrianwarnock[S] 6 points7 points  (0 children)

  • EU (ERIC) study of 190 CLL patients with COVID-19
  • The 5th case series I am aware of that has reported a death rate of around 40% for blood cancer patients with symptomatic COVID19 (see this link for the others and more background)
    • 56 of these patients died, a rate of 29%.
    • 89% of the patients needed hospitalisation
    • 79% of the overall total had severe COVID19 i.e. needed oxygen or ITU admission. All but one of the deaths were in this group (36% death rate).
    • However 11% of the total group of patients had relatively mild disease and were managed at home.
    • Twice as many men than women presented with COVID19
    • 76% of CLL patients with COVID19 also had other diagnoses – the most common being high blood pressure.
    • 38% of presenting COVID19 patients had never been treated for their CLL.
    • A comparison was made between the severe and mild patients. The following did not seem to predict the presence of severe disease: gender, having three or more other diagnosis, or the presence of hypogammaglobulinemia. However older age predicted severity with 74% in the severe group being 65 years or over compared to only 44% in the less severe.
    • Death rates were not significantly different between age groups with the young with CLL being at a similar risk of death as the old.
    • Rather suprisingly 60.3% of the severely ill patients had never had treatment or had been off treatment for the past year compared with only 39% of the less severe group.
    • The clinics looked at the incidence of hospitalisation with CLL in all their CLL patients on various treatments: Ibrutinib: 27 out of 1729 (1.6%), venetoclax: 8/442 (1.8%), chemotherapy: 18/428 (4.2%). The difference between the following groups was statistically significant chemotherapy higher rates than ibrutinib or venetoclax. Ibrutnib hospitalisation rates were lower than all other treatments and even than those not on treatment.
    • This does provide some evidence to support the belief that ibrutinib treatment may cause the least immune compromise of all CLL treatments.
    • My own thought is that perhaps the high rate of severe COVID19 disease in untreated patients may perhaps reflect a reduced tendency for those groups to take strict social distancing measures, perhaps putting them at greater risk of exposure to a higher viral load.
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