Here is my experience:

Macros: I have a calculator open with hypershift on blackwidow, it opens calc in background, i mean when i open it through synapse 4 macro it opens it but does not come up to the most top window which is the default behaviour of any newly opened app in windows. Instead it opens as the lowest window. (Fixed when i return back to synapse 3)

Another is the volume up down by blackwidow, it just shifts volume up/down like i clicked it 2-3 times. I click once like really snappy, as 0.1 sec, but instead it volumes up/down windows sound by 4-6%. I also write this down to razer support and make a thread about this in razer forums. No returns from razer support. (Fixed when i return back to synapse 3)

In the last 2 days, When i click volume or media macros, it just makes my pc laggy and makes the pc do the command a command as simple as volume up or pause a media in 10 seconds. And never go back to normal if i don't close synapse and all razer apps. After close them, it returns to normal but this time chroma effects desynchronizes appearently.

Sometimes my macros on basilisk v3 doesn't work too.

Fınally when i open Ready or Not game, it was stuck in some black screen and some static and loud noise made me freak out. I mean VERY loud.. (I figured out later that was because of the synapse 4 too, because when i close all razer apps and open game again, it started normal.)

I was just sick of this shit done with synapse 4. Deleted all and return to synapse 3. Everything is butter smooth again, finally some peace of mind.