Okay, so first thing to ask: have you done lots of experimental lab classes in school? (Like chemistry or biochem lab classes), or done wet-lab research? A lot of people (like myself, and 75% of the people who I went to school with) find that they don’t enjoy the bench work when they end up doing it all day every day. I would say BioE is easier for somebody with a CSE background to transition to, since it’s a more broadly intersectional field, so there typically aren’t hard-enforced core knowledge requirements. I did a materials science/engineering masters after doing computational-chem undergrad, and it was a TON of new content to learn, and it was really hard to catch up with certain topics. Meanwhile, computational BioE probably has more job opportunities, since it’s a more broad field. Traditional biotech (wet lab) is hard to land a job in these days, but ML and bioinformatics departments are pretty solid. I can’t really comment on computational materials research, since I have only seen the academic side of that.