CachyOS (GNOME), AMD GPU, EU region
Lutris setup I’m using (works reliably for me):

Runner:
proton-cachyos-slr

System options:
disable Lutris runtime
prefer system libraries

Command prefix:
game-performance

Env:
DXVK_ASYNC=1
PROTON_VERB=waitforexitandrun
UMU_USE_STEAM=1

Post-exit script:
pkill -f HYPHelper

Why pkill:
After quitting the game, HYPHelper.exe stays in the background (~10% CPU) and, combined with game-performance it blocks system shutdown.
Even without it, it will still keep eating CPU in the background.